Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19

Progressive decrease in the weight and functional reserve of β-cells is one of the main pathogenetic mechanisms of development of type 2 diabetes mellitus (DM2). The rate of progression of these processes is strictly individual, which largely determines the course of DM2 and the effectivene...

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Autores principales:	Z. A. Kalmykova, I. V. Kononenko, I. A. Sklyanik, M. V. Shestakova, N. G. Mokrysheva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	covid-19 sars-cov-2 stress hyperglycemia β-cell “cytokine storm” Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/62260d1579e642eebf8122da7935c08c
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spelling	oai:doaj.org-article:62260d1579e642eebf8122da7935c08c2021-11-14T09:00:23ZHyperglycemia and possible mechanisms of β-cell damage in patients with COVID-192072-03512072-037810.14341/DM12485https://doaj.org/article/62260d1579e642eebf8122da7935c08c2020-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12485https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Progressive decrease in the weight and functional reserve of β-cells is one of the main pathogenetic mechanisms of development of type 2 diabetes mellitus (DM2). The rate of progression of these processes is strictly individual, which largely determines the course of DM2 and the effectiveness of the therapy. As a rule, apoptosis and necrosis are the main mechanisms of β-cell damage and death in CD2. At the same time, recent studies allow us to consider the destruction and death of β-cells as the outcome of other types of programmed cell death (PCG), the role of innate immunity in the Genesis of CD2 IS actively discussed. This article provides an overview of the data of domestic and foreign literature of recent years regarding the molecular, intracellular characteristics of different types of β-cell PCG in CD2. The results of studies aimed at studying the possible factors and processes leading to their launch are presented.Z. A. KalmykovaI. V. KononenkoI. A. SklyanikM. V. ShestakovaN. G. MokryshevaEndocrinology Research Centrearticlecovid-19sars-cov-2stress hyperglycemiaβ-cell“cytokine storm”Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 3, Pp 229-234 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	covid-19 sars-cov-2 stress hyperglycemia β-cell “cytokine storm” Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	covid-19 sars-cov-2 stress hyperglycemia β-cell “cytokine storm” Nutritional diseases. Deficiency diseases RC620-627 Z. A. Kalmykova I. V. Kononenko I. A. Sklyanik M. V. Shestakova N. G. Mokrysheva Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
description	Progressive decrease in the weight and functional reserve of β-cells is one of the main pathogenetic mechanisms of development of type 2 diabetes mellitus (DM2). The rate of progression of these processes is strictly individual, which largely determines the course of DM2 and the effectiveness of the therapy. As a rule, apoptosis and necrosis are the main mechanisms of β-cell damage and death in CD2. At the same time, recent studies allow us to consider the destruction and death of β-cells as the outcome of other types of programmed cell death (PCG), the role of innate immunity in the Genesis of CD2 IS actively discussed. This article provides an overview of the data of domestic and foreign literature of recent years regarding the molecular, intracellular characteristics of different types of β-cell PCG in CD2. The results of studies aimed at studying the possible factors and processes leading to their launch are presented.
format	article
author	Z. A. Kalmykova I. V. Kononenko I. A. Sklyanik M. V. Shestakova N. G. Mokrysheva
author_facet	Z. A. Kalmykova I. V. Kononenko I. A. Sklyanik M. V. Shestakova N. G. Mokrysheva
author_sort	Z. A. Kalmykova
title	Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
title_short	Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
title_full	Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
title_fullStr	Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
title_full_unstemmed	Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19
title_sort	hyperglycemia and possible mechanisms of β-cell damage in patients with covid-19
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/62260d1579e642eebf8122da7935c08c
work_keys_str_mv	AT zakalmykova hyperglycemiaandpossiblemechanismsofbcelldamageinpatientswithcovid19 AT ivkononenko hyperglycemiaandpossiblemechanismsofbcelldamageinpatientswithcovid19 AT iasklyanik hyperglycemiaandpossiblemechanismsofbcelldamageinpatientswithcovid19 AT mvshestakova hyperglycemiaandpossiblemechanismsofbcelldamageinpatientswithcovid19 AT ngmokrysheva hyperglycemiaandpossiblemechanismsofbcelldamageinpatientswithcovid19
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Hyperglycemia and possible mechanisms of β-cell damage in patients with COVID-19

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