A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis
Abstract Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential...
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Nature Portfolio
2021
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oai:doaj.org-article:62264b02f54944668c0b990d0a7184cf2021-12-02T10:48:03ZA clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis10.1038/s41598-021-81931-z2045-2322https://doaj.org/article/62264b02f54944668c0b990d0a7184cf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81931-zhttps://doaj.org/toc/2045-2322Abstract Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential of the Lacticaseibacillus rhamnosus TOM 22.8 strain, isolated from the vaginal ecosystem of a healthy woman. For this purpose, safety and functional properties were in depth evaluated. The strain exhibited a broad spectrum of antagonistic activity against vaginal pathogens; adhesion capacity to both the vaginal VK2/E6E7 and the intestinal Caco-2 cells; anti-inflammatory and antioxidant activities, suggesting its promising probiotic features. In addition, an in vivo pilot-study was planned. Based on both clinical and microbiological parameters, the oral or vaginal strain administration, determined a significant pathogens reduction after 10 days of administration and a maintenance of eubiosis up to 30 days after the end of the treatment. Therefore, the L. rhamnosus TOM 22.8 strain can be proposed as valuable oral and/or vaginal treatment for vaginal dysbiosis.Alessandra PinoAgnese Maria Chiara RapisardaSalvatore Giovanni VitaleStefano CianciCinzia CaggiaCinzia Lucia RandazzoAntonio CianciNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Alessandra Pino Agnese Maria Chiara Rapisarda Salvatore Giovanni Vitale Stefano Cianci Cinzia Caggia Cinzia Lucia Randazzo Antonio Cianci A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| description |
Abstract Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential of the Lacticaseibacillus rhamnosus TOM 22.8 strain, isolated from the vaginal ecosystem of a healthy woman. For this purpose, safety and functional properties were in depth evaluated. The strain exhibited a broad spectrum of antagonistic activity against vaginal pathogens; adhesion capacity to both the vaginal VK2/E6E7 and the intestinal Caco-2 cells; anti-inflammatory and antioxidant activities, suggesting its promising probiotic features. In addition, an in vivo pilot-study was planned. Based on both clinical and microbiological parameters, the oral or vaginal strain administration, determined a significant pathogens reduction after 10 days of administration and a maintenance of eubiosis up to 30 days after the end of the treatment. Therefore, the L. rhamnosus TOM 22.8 strain can be proposed as valuable oral and/or vaginal treatment for vaginal dysbiosis. |
| format |
article |
| author |
Alessandra Pino Agnese Maria Chiara Rapisarda Salvatore Giovanni Vitale Stefano Cianci Cinzia Caggia Cinzia Lucia Randazzo Antonio Cianci |
| author_facet |
Alessandra Pino Agnese Maria Chiara Rapisarda Salvatore Giovanni Vitale Stefano Cianci Cinzia Caggia Cinzia Lucia Randazzo Antonio Cianci |
| author_sort |
Alessandra Pino |
| title |
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| title_short |
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| title_full |
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| title_fullStr |
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| title_full_unstemmed |
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis |
| title_sort |
clinical pilot study on the effect of the probiotic lacticaseibacillus rhamnosus tom 22.8 strain in women with vaginal dysbiosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/62264b02f54944668c0b990d0a7184cf |
| work_keys_str_mv |
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