Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview

Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, S&atilde...

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Autores principales:	Lallo da Silva B, Abuçafy MP, Berbel Manaia E, Oshiro Junior JA, Chiari-Andréo BG, Pietro RCLR, Chiavacci LA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nanoparticles zinc oxide antimicrobial activity toxicity mechanisms. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/622eeab74f81419ebda670475d7b95c7
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spelling	oai:doaj.org-article:622eeab74f81419ebda670475d7b95c72021-12-02T04:49:17ZRelationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview1178-2013https://doaj.org/article/622eeab74f81419ebda670475d7b95c72019-12-01T00:00:00Zhttps://www.dovepress.com/relationship-between-structure-and-antimicrobial-activity-of-zinc-oxid-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil; 2Department of Biological and Health Sciences, Universidade De Araraquara, UNIARA, Araraquara, SP, BrazilCorrespondence: Leila Aparecida ChiavacciDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jaú, km 1 – s/n Campos Ville, Araraquara, SP, BrazilTel +55 16 33016966Fax +55 16 33016900Email leila@fcfar.unesp.brAbstract: The inappropriate use of antimicrobials has resulted in the selection of resistant strains. Thus, a great number of studies have focused on the investigation of new antimicrobial agents. The use of zinc oxide nanoparticles (ZnO NPs) to optimise the fight against microbial resistance has been receiving increased attention due to the non-specific activity of inorganic antimicrobial agents. The small particle size and the high surface area of ZnO NPs can enhance antimicrobial activity, causing an improvement in surface reactivity. In addition, surface modifiers covering ZnO NPs can play a role in mediating antimicrobial activity since the surface properties of nanomaterials alter their interactions with cells; this may interfere with the antimicrobial effect of ZnO NPs. The possibility of using surface modifiers with groups toxic to microorganisms can improve the antimicrobial activity of ZnO NPs. Understanding the exact toxicity mechanisms is crucial to elucidating the antimicrobial activity of ZnO NPs in bacteria and fungi. Therefore, this review aims to describe the mechanisms of ZnO NPs toxicity against fungi and bacteria and how the different structural and physical-chemical characteristics of ZnO NPs can interfere in their antimicrobial activity.Keywords: nanoparticles, zinc oxide, antimicrobial activity, toxicity mechanismsLallo da Silva BAbuçafy MPBerbel Manaia EOshiro Junior JAChiari-Andréo BGPietro RCLRChiavacci LADove Medical Pressarticlenanoparticleszinc oxideantimicrobial activitytoxicity mechanisms.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9395-9410 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles zinc oxide antimicrobial activity toxicity mechanisms. Medicine (General) R5-920
spellingShingle	nanoparticles zinc oxide antimicrobial activity toxicity mechanisms. Medicine (General) R5-920 Lallo da Silva B Abuçafy MP Berbel Manaia E Oshiro Junior JA Chiari-Andréo BG Pietro RCLR Chiavacci LA Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
description	Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil; 2Department of Biological and Health Sciences, Universidade De Araraquara, UNIARA, Araraquara, SP, BrazilCorrespondence: Leila Aparecida ChiavacciDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jaú, km 1 – s/n Campos Ville, Araraquara, SP, BrazilTel +55 16 33016966Fax +55 16 33016900Email leila@fcfar.unesp.brAbstract: The inappropriate use of antimicrobials has resulted in the selection of resistant strains. Thus, a great number of studies have focused on the investigation of new antimicrobial agents. The use of zinc oxide nanoparticles (ZnO NPs) to optimise the fight against microbial resistance has been receiving increased attention due to the non-specific activity of inorganic antimicrobial agents. The small particle size and the high surface area of ZnO NPs can enhance antimicrobial activity, causing an improvement in surface reactivity. In addition, surface modifiers covering ZnO NPs can play a role in mediating antimicrobial activity since the surface properties of nanomaterials alter their interactions with cells; this may interfere with the antimicrobial effect of ZnO NPs. The possibility of using surface modifiers with groups toxic to microorganisms can improve the antimicrobial activity of ZnO NPs. Understanding the exact toxicity mechanisms is crucial to elucidating the antimicrobial activity of ZnO NPs in bacteria and fungi. Therefore, this review aims to describe the mechanisms of ZnO NPs toxicity against fungi and bacteria and how the different structural and physical-chemical characteristics of ZnO NPs can interfere in their antimicrobial activity.Keywords: nanoparticles, zinc oxide, antimicrobial activity, toxicity mechanisms
format	article
author	Lallo da Silva B Abuçafy MP Berbel Manaia E Oshiro Junior JA Chiari-Andréo BG Pietro RCLR Chiavacci LA
author_facet	Lallo da Silva B Abuçafy MP Berbel Manaia E Oshiro Junior JA Chiari-Andréo BG Pietro RCLR Chiavacci LA
author_sort	Lallo da Silva B
title	Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
title_short	Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
title_full	Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
title_fullStr	Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
title_full_unstemmed	Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
title_sort	relationship between structure and antimicrobial activity of zinc oxide nanoparticles: an overview
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/622eeab74f81419ebda670475d7b95c7
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Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview

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