Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach

Hydrogels warrant attention as a potential material for use in sustained pulmonary drug delivery due to their swelling and mucoadhesive features. Herein, hyaluronic acid (HA) is considered a promising material due to its therapeutic potential, the effect on lung inflammation, and possible utility as...

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Autores principales:	Dariush Nikjoo, Irès van der Zwaan, Mikael Brülls, Ulrika Tehler, Göran Frenning
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyaluronic acid salbutamol sulphate spray-drying urea glutaraldehyde drug delivery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/623092c3afa84d938af1895dd26c8bea
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spelling	oai:doaj.org-article:623092c3afa84d938af1895dd26c8bea2021-11-25T18:41:23ZHyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach10.3390/pharmaceutics131118781999-4923https://doaj.org/article/623092c3afa84d938af1895dd26c8bea2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1878https://doaj.org/toc/1999-4923Hydrogels warrant attention as a potential material for use in sustained pulmonary drug delivery due to their swelling and mucoadhesive features. Herein, hyaluronic acid (HA) is considered a promising material due to its therapeutic potential, the effect on lung inflammation, and possible utility as an excipient or drug carrier. In this study, the feasibility of using HA hydrogels (without a model drug) to engineer inhalation powders for controlled pulmonary drug delivery was assessed. A combination of chemical crosslinking and spray-drying was proposed as a novel methodology for the preparation of inhalation powders. Different crosslinkers (urea; UR and glutaraldehyde; GA) were exploited in the hydrogel formulation and the obtained powders were subjected to extensive characterization. Compositional analysis of the powders indicated a crosslinked structure of the hydrogels with sufficient thermal stability to withstand spray drying. The obtained microparticles presented a spherical shape with mean diameter particle sizes from 2.3 ± 1.1 to 3.2 ± 2.9 μm. Microparticles formed from HA crosslinked with GA exhibited a reasonable aerosolization performance (fine particle fraction estimated as 28 ± 2%), whereas lower values were obtained for the UR-based formulation. Likewise, swelling and stability in water were larger for GA than for UR, for which the results were very similar to those obtained for native (not crosslinked) HA. In conclusion, microparticles could successfully be produced from crosslinked HA, and the ones crosslinked by GA exhibited superior performance in terms of aerosolization and swelling.Dariush NikjooIrès van der ZwaanMikael BrüllsUlrika TehlerGöran FrenningMDPI AGarticlehyaluronic acidsalbutamol sulphatespray-dryingureaglutaraldehydedrug deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1878, p 1878 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyaluronic acid salbutamol sulphate spray-drying urea glutaraldehyde drug delivery Pharmacy and materia medica RS1-441
spellingShingle	hyaluronic acid salbutamol sulphate spray-drying urea glutaraldehyde drug delivery Pharmacy and materia medica RS1-441 Dariush Nikjoo Irès van der Zwaan Mikael Brülls Ulrika Tehler Göran Frenning Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
description	Hydrogels warrant attention as a potential material for use in sustained pulmonary drug delivery due to their swelling and mucoadhesive features. Herein, hyaluronic acid (HA) is considered a promising material due to its therapeutic potential, the effect on lung inflammation, and possible utility as an excipient or drug carrier. In this study, the feasibility of using HA hydrogels (without a model drug) to engineer inhalation powders for controlled pulmonary drug delivery was assessed. A combination of chemical crosslinking and spray-drying was proposed as a novel methodology for the preparation of inhalation powders. Different crosslinkers (urea; UR and glutaraldehyde; GA) were exploited in the hydrogel formulation and the obtained powders were subjected to extensive characterization. Compositional analysis of the powders indicated a crosslinked structure of the hydrogels with sufficient thermal stability to withstand spray drying. The obtained microparticles presented a spherical shape with mean diameter particle sizes from 2.3 ± 1.1 to 3.2 ± 2.9 μm. Microparticles formed from HA crosslinked with GA exhibited a reasonable aerosolization performance (fine particle fraction estimated as 28 ± 2%), whereas lower values were obtained for the UR-based formulation. Likewise, swelling and stability in water were larger for GA than for UR, for which the results were very similar to those obtained for native (not crosslinked) HA. In conclusion, microparticles could successfully be produced from crosslinked HA, and the ones crosslinked by GA exhibited superior performance in terms of aerosolization and swelling.
format	article
author	Dariush Nikjoo Irès van der Zwaan Mikael Brülls Ulrika Tehler Göran Frenning
author_facet	Dariush Nikjoo Irès van der Zwaan Mikael Brülls Ulrika Tehler Göran Frenning
author_sort	Dariush Nikjoo
title	Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
title_short	Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
title_full	Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
title_fullStr	Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
title_full_unstemmed	Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach
title_sort	hyaluronic acid hydrogels for controlled pulmonary drug delivery—a particle engineering approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/623092c3afa84d938af1895dd26c8bea
work_keys_str_mv	AT dariushnikjoo hyaluronicacidhydrogelsforcontrolledpulmonarydrugdeliveryaparticleengineeringapproach AT iresvanderzwaan hyaluronicacidhydrogelsforcontrolledpulmonarydrugdeliveryaparticleengineeringapproach AT mikaelbrulls hyaluronicacidhydrogelsforcontrolledpulmonarydrugdeliveryaparticleengineeringapproach AT ulrikatehler hyaluronicacidhydrogelsforcontrolledpulmonarydrugdeliveryaparticleengineeringapproach AT goranfrenning hyaluronicacidhydrogelsforcontrolledpulmonarydrugdeliveryaparticleengineeringapproach
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Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach

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