The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health an...

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Autores principales:	Xianpeng Xu, Jinke Huang, Simin Wu, Qingjie Ji, Xuguang Guo, Yong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi-Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6230ca49dd424964845d0569d9c79c36
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spelling	oai:doaj.org-article:6230ca49dd424964845d0569d9c79c362021-11-08T02:36:45ZThe Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults1755-592210.1155/2021/4626062https://doaj.org/article/6230ca49dd424964845d0569d9c79c362021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4626062https://doaj.org/toc/1755-5922Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.Xianpeng XuJinke HuangSimin WuQingjie JiXuguang GuoYong HuangHindawi-WileyarticleTherapeutics. PharmacologyRM1-950Diseases of the circulatory (Cardiovascular) systemRC666-701ENCardiovascular Therapeutics, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701 Xianpeng Xu Jinke Huang Simin Wu Qingjie Ji Xuguang Guo Yong Huang The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
description	Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.
format	article
author	Xianpeng Xu Jinke Huang Simin Wu Qingjie Ji Xuguang Guo Yong Huang
author_facet	Xianpeng Xu Jinke Huang Simin Wu Qingjie Ji Xuguang Guo Yong Huang
author_sort	Xianpeng Xu
title	The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
title_short	The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
title_full	The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
title_fullStr	The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
title_full_unstemmed	The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
title_sort	association between the serum uric acid level and hypertension in middle-aged and elderly adults
publisher	Hindawi-Wiley
publishDate	2021
url	https://doaj.org/article/6230ca49dd424964845d0569d9c79c36
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The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

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