Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?

Michael Bietenbeck,1 Anca Florian,1 Cornelius Faber,2 Udo Sechtem,3 Ali Yilmaz11Department of Cardiology and Angiology, 2Department of Clinical Radiology, University Hospital Münster, Münster, 3Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany Abstract: Magnetic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bietenbeck M, Florian A, Faber C, Sechtem U, Yilmaz A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	MRI CMR magnetic targeting SPIO myocardial infarction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/62314f5a206345f99b8c31781e4412a5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62314f5a206345f99b8c31781e4412a5
record_format	dspace
spelling	oai:doaj.org-article:62314f5a206345f99b8c31781e4412a52021-12-02T02:40:52ZRemote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?1178-2013https://doaj.org/article/62314f5a206345f99b8c31781e4412a52016-07-01T00:00:00Zhttps://www.dovepress.com/remote-magnetic-targeting-of-iron-oxide-nanoparticles-for-cardiovascul-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Michael Bietenbeck,1 Anca Florian,1 Cornelius Faber,2 Udo Sechtem,3 Ali Yilmaz11Department of Cardiology and Angiology, 2Department of Clinical Radiology, University Hospital Münster, Münster, 3Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany Abstract: Magnetic resonance imaging (MRI) allows for an accurate assessment of both functional and structural cardiac parameters, and thereby appropriate diagnosis and validation of cardiovascular diseases. The diagnostic yield of cardiovascular MRI examinations is often increased by the use of contrast agents that are almost exclusively based on gadolinium compounds. Another clinically approved contrast medium is composed of superparamagnetic iron oxide nanoparticles (IONs). These particles may expand the field of contrast-enhanced cardiovascular MRI as recently shown in clinical studies focusing on acute myocardial infarction (AMI) and atherosclerosis. Furthermore, IONs open up new research opportunities such as remote magnetic drug targeting (MDT). The approach of MDT relies on the coupling of bioactive molecules and magnetic nanoparticles to form an injectable complex. This complex, in turn, can be attracted to and retained at a desired target inside the body with the help of applied magnetic fields. In comparison to common systemic drug applications, MDT techniques promise both higher concentrations at the target site and lower concentrations elsewhere in the body. Moreover, concurrent or subsequent MRI can be used for noninvasive monitoring of drug distribution and successful delivery to the desired organ in vivo. This review does not only illustrate the basic conceptual and biophysical principles of IONs, but also focuses on new research activities and achievements in the cardiovascular field, mainly in the management of AMI. Based on the presentation of successful MDT applications in preclinical models of AMI, novel approaches and the translational potential of MDT are discussed.Keywords: MRI, CMR, magnetic targeting, SPION, myocardial infarctionBietenbeck MFlorian AFaber CSechtem UYilmaz ADove Medical PressarticleMRICMRmagnetic targetingSPIOmyocardial infarctionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3191-3203 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	MRI CMR magnetic targeting SPIO myocardial infarction Medicine (General) R5-920
spellingShingle	MRI CMR magnetic targeting SPIO myocardial infarction Medicine (General) R5-920 Bietenbeck M Florian A Faber C Sechtem U Yilmaz A Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
description	Michael Bietenbeck,1 Anca Florian,1 Cornelius Faber,2 Udo Sechtem,3 Ali Yilmaz11Department of Cardiology and Angiology, 2Department of Clinical Radiology, University Hospital Münster, Münster, 3Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany Abstract: Magnetic resonance imaging (MRI) allows for an accurate assessment of both functional and structural cardiac parameters, and thereby appropriate diagnosis and validation of cardiovascular diseases. The diagnostic yield of cardiovascular MRI examinations is often increased by the use of contrast agents that are almost exclusively based on gadolinium compounds. Another clinically approved contrast medium is composed of superparamagnetic iron oxide nanoparticles (IONs). These particles may expand the field of contrast-enhanced cardiovascular MRI as recently shown in clinical studies focusing on acute myocardial infarction (AMI) and atherosclerosis. Furthermore, IONs open up new research opportunities such as remote magnetic drug targeting (MDT). The approach of MDT relies on the coupling of bioactive molecules and magnetic nanoparticles to form an injectable complex. This complex, in turn, can be attracted to and retained at a desired target inside the body with the help of applied magnetic fields. In comparison to common systemic drug applications, MDT techniques promise both higher concentrations at the target site and lower concentrations elsewhere in the body. Moreover, concurrent or subsequent MRI can be used for noninvasive monitoring of drug distribution and successful delivery to the desired organ in vivo. This review does not only illustrate the basic conceptual and biophysical principles of IONs, but also focuses on new research activities and achievements in the cardiovascular field, mainly in the management of AMI. Based on the presentation of successful MDT applications in preclinical models of AMI, novel approaches and the translational potential of MDT are discussed.Keywords: MRI, CMR, magnetic targeting, SPION, myocardial infarction
format	article
author	Bietenbeck M Florian A Faber C Sechtem U Yilmaz A
author_facet	Bietenbeck M Florian A Faber C Sechtem U Yilmaz A
author_sort	Bietenbeck M
title	Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
title_short	Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
title_full	Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
title_fullStr	Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
title_full_unstemmed	Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
title_sort	remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/62314f5a206345f99b8c31781e4412a5
work_keys_str_mv	AT bietenbeckm remotemagnetictargetingofironoxidenanoparticlesforcardiovasculardiagnosisandtherapeuticdrugdeliverywherearewenow AT floriana remotemagnetictargetingofironoxidenanoparticlesforcardiovasculardiagnosisandtherapeuticdrugdeliverywherearewenow AT faberc remotemagnetictargetingofironoxidenanoparticlesforcardiovasculardiagnosisandtherapeuticdrugdeliverywherearewenow AT sechtemu remotemagnetictargetingofironoxidenanoparticlesforcardiovasculardiagnosisandtherapeuticdrugdeliverywherearewenow AT yilmaza remotemagnetictargetingofironoxidenanoparticlesforcardiovasculardiagnosisandtherapeuticdrugdeliverywherearewenow
_version_	1718402288566927360

Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?

Ejemplares similares