Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.

<h4>Background</h4>Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephr...

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Autores principales:	Stefan H van Vuuren, Chalana M Sol, Roel Broekhuizen, Marc R Lilien, Michiel J S Oosterveld, Tri Q Nguyen, Roel Goldschmeding, Tom P V M de Jong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6232052cbbe24535b426f6ec893eed1f
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spelling	oai:doaj.org-article:6232052cbbe24535b426f6ec893eed1f2021-11-18T08:07:55ZCompensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.1932-620310.1371/journal.pone.0049735https://doaj.org/article/6232052cbbe24535b426f6ec893eed1f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185419/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephron hypertrophy is unresolved. This question is of utmost clinical importance, since hypertrophy is associated with a risk of developing hypertension and proteinuria later in life with consequent development of CKD and cardiovascular disease.<h4>Methodology/principal findings</h4>In a cohort of 32,000 slaughter pigs, 7 congenital solitary functioning kidneys and 7 control kidneys were identified and harvested. Cortex volume was measured and with a 3-dimensional stereologic technique the number and volume of glomeruli was determined and compared. The mean total cortex volume was increased by more than 80% and the mean number of glomeruli per kidney was 50% higher in CSFKs than in a single control kidney, equaling 75% of the total nephron number in both kidneys of control subjects. The mean total glomerular volume in the CSFKs was not increased relative to the controls.<h4>Conclusions/significance</h4>Thus, in pigs, compensatory enlargement of a CSFK is based on increased nephron numbers. Extrapolation of these findings to the human situation suggests that patients with a CSFK might not be at increased risk for developing hyperfiltration-associated renal and cardiovascular disease in later life due to a lower nephron number.Stefan H van VuurenChalana M SolRoel BroekhuizenMarc R LilienMichiel J S OosterveldTri Q NguyenRoel GoldschmedingTom P V M de JongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49735 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan H van Vuuren Chalana M Sol Roel Broekhuizen Marc R Lilien Michiel J S Oosterveld Tri Q Nguyen Roel Goldschmeding Tom P V M de Jong Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
description	<h4>Background</h4>Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephron hypertrophy is unresolved. This question is of utmost clinical importance, since hypertrophy is associated with a risk of developing hypertension and proteinuria later in life with consequent development of CKD and cardiovascular disease.<h4>Methodology/principal findings</h4>In a cohort of 32,000 slaughter pigs, 7 congenital solitary functioning kidneys and 7 control kidneys were identified and harvested. Cortex volume was measured and with a 3-dimensional stereologic technique the number and volume of glomeruli was determined and compared. The mean total cortex volume was increased by more than 80% and the mean number of glomeruli per kidney was 50% higher in CSFKs than in a single control kidney, equaling 75% of the total nephron number in both kidneys of control subjects. The mean total glomerular volume in the CSFKs was not increased relative to the controls.<h4>Conclusions/significance</h4>Thus, in pigs, compensatory enlargement of a CSFK is based on increased nephron numbers. Extrapolation of these findings to the human situation suggests that patients with a CSFK might not be at increased risk for developing hyperfiltration-associated renal and cardiovascular disease in later life due to a lower nephron number.
format	article
author	Stefan H van Vuuren Chalana M Sol Roel Broekhuizen Marc R Lilien Michiel J S Oosterveld Tri Q Nguyen Roel Goldschmeding Tom P V M de Jong
author_facet	Stefan H van Vuuren Chalana M Sol Roel Broekhuizen Marc R Lilien Michiel J S Oosterveld Tri Q Nguyen Roel Goldschmeding Tom P V M de Jong
author_sort	Stefan H van Vuuren
title	Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
title_short	Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
title_full	Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
title_fullStr	Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
title_full_unstemmed	Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
title_sort	compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6232052cbbe24535b426f6ec893eed1f
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Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.

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