Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia

Abstract Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizop...

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Autores principales:	Lixue Xu, Wen Qin, Chuanjun Zhuo, Huaigui Liu, Jiajia Zhu, Chunshui Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6232085c561b47c49c3a38591e23fe8e
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spelling	oai:doaj.org-article:6232085c561b47c49c3a38591e23fe8e2021-12-02T11:40:22ZCombination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia10.1038/s41598-017-00352-z2045-2322https://doaj.org/article/6232085c561b47c49c3a38591e23fe8e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00352-zhttps://doaj.org/toc/2045-2322Abstract Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizophrenia based on grey matter volume (GMV) and cerebral blood flow (CBF). Structural and perfusion magnetic resonance imaging data were acquired in 100 schizophrenia patients and 95 healthy comparison subjects. Voxel-based GMV comparison was used to show structural changes, CBF analysis was used to demonstrate functional changes. We identified three types of grey matter changes in schizophrenia: structural and functional impairments in the anterior cingulate cortex and insular cortex, displaying reduction in both GMV and CBF; structural impairment with preserved function in the frontal and temporal cortices, demonstrating decreased GMV with normal CBF; pure functional abnormality in the anterior cingulate cortex and lateral prefrontal cortex and putamen, showing altered CBF with normal GMV. By combination of GMV and CBF, we identified three types of grey matter changes in schizophrenia. These findings may help to understand the complex manifestations and to develop reliable biomarkers in schizophrenia.Lixue XuWen QinChuanjun ZhuoHuaigui LiuJiajia ZhuChunshui YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lixue Xu Wen Qin Chuanjun Zhuo Huaigui Liu Jiajia Zhu Chunshui Yu Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
description	Abstract Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizophrenia based on grey matter volume (GMV) and cerebral blood flow (CBF). Structural and perfusion magnetic resonance imaging data were acquired in 100 schizophrenia patients and 95 healthy comparison subjects. Voxel-based GMV comparison was used to show structural changes, CBF analysis was used to demonstrate functional changes. We identified three types of grey matter changes in schizophrenia: structural and functional impairments in the anterior cingulate cortex and insular cortex, displaying reduction in both GMV and CBF; structural impairment with preserved function in the frontal and temporal cortices, demonstrating decreased GMV with normal CBF; pure functional abnormality in the anterior cingulate cortex and lateral prefrontal cortex and putamen, showing altered CBF with normal GMV. By combination of GMV and CBF, we identified three types of grey matter changes in schizophrenia. These findings may help to understand the complex manifestations and to develop reliable biomarkers in schizophrenia.
format	article
author	Lixue Xu Wen Qin Chuanjun Zhuo Huaigui Liu Jiajia Zhu Chunshui Yu
author_facet	Lixue Xu Wen Qin Chuanjun Zhuo Huaigui Liu Jiajia Zhu Chunshui Yu
author_sort	Lixue Xu
title	Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
title_short	Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
title_full	Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
title_fullStr	Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
title_full_unstemmed	Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
title_sort	combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6232085c561b47c49c3a38591e23fe8e
work_keys_str_mv	AT lixuexu combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia AT wenqin combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia AT chuanjunzhuo combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia AT huaiguiliu combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia AT jiajiazhu combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia AT chunshuiyu combinationofvolumeandperfusionparametersrevealsdifferenttypesofgreymatterchangesinschizophrenia
_version_	1718395645779247104

Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia

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