Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which bind to RGD-containing ligands. However, compu...

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Auteurs principaux: Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
RGD
Accès en ligne:https://doaj.org/article/6232723385df46bc893a5afb2e3780ce
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