The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study

Ahmed M Bawazeer,1,2 Heba Ismail Joharjy1 1Uveitis Services, Department of Ophthalmology, King Abdulaziz University, 2Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia Background: The association of human leukocyte antigen B27 (HLA-B27) with anterior uveitis is well known. The prevalence of HLA-B27...

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Autores principales:	Bawazeer AM, Joharjy HI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6235ead769a24a2e85e1b9d952037065
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spelling	oai:doaj.org-article:6235ead769a24a2e85e1b9d9520370652021-12-02T00:56:32ZThe association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study1177-54671177-5483https://doaj.org/article/6235ead769a24a2e85e1b9d9520370652013-10-01T00:00:00Zhttp://www.dovepress.com/the-association-of-human-leukocyte-antigen-b27-with-anterior-uveitis-i-a14824https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ahmed M Bawazeer,1,2 Heba Ismail Joharjy1 1Uveitis Services, Department of Ophthalmology, King Abdulaziz University, 2Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia Background: The association of human leukocyte antigen B27 (HLA-B27) with anterior uveitis is well known. The prevalence of HLA-B27 and its relation to anterior uveitis is related to race and geographic location. The association is strongest in Western countries and weakest in Eastern countries. Data regarding this association from Middle Eastern countries are limited. Thus, we undertook the study reported here to evaluate the association of HLA-B27 with anterior uveitis in patients in a tertiary center in the western region of the Saudi Arabia. Methods: The study involved a retrospective analysis of the records of patients with anterior uveitis, referred to the uveitis clinic in Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia, from 1999 to 2010. The cost-effectiveness of HLA-B27 testing was analyzed. Results: Among the 587 cases of uveitis, 335 (57.1%; mean age 37.56±12.82 years; 203 male and 132 female) cases were of anterior uveitis. All patients with anterior uveitis were investigated for HLA-B27 positivity. Idiopathic anterior uveitis was the most common (80%), followed by Fuchs heterochromic cyclitis (7.45%) and ankylosing spondylitis (3.8%). Only two patients were HLA-B27 positive. The cost-effectiveness of HLA-B27 testing was found to be 165,000 Saudi riyals (44,594 US dollars) per positive case. Conclusion: HLA-B27-related uveitis appears to be very rare in our part of the world. Idiopathic uveitis is the most common type of anterior uveitis. The cost-effectiveness of HLA-B27 testing is low for patients with anterior uveitis in the western region of Saudi Arabia. Keywords: HLA-B27, Saudi population, cost-effectiveness, idiopathic anterior uveitis, Fuchs heterochromic cyclitis, ankylosing spondylitisBawazeer AMJoharjy HIDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2107-2111 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Bawazeer AM Joharjy HI The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
description	Ahmed M Bawazeer,1,2 Heba Ismail Joharjy1 1Uveitis Services, Department of Ophthalmology, King Abdulaziz University, 2Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia Background: The association of human leukocyte antigen B27 (HLA-B27) with anterior uveitis is well known. The prevalence of HLA-B27 and its relation to anterior uveitis is related to race and geographic location. The association is strongest in Western countries and weakest in Eastern countries. Data regarding this association from Middle Eastern countries are limited. Thus, we undertook the study reported here to evaluate the association of HLA-B27 with anterior uveitis in patients in a tertiary center in the western region of the Saudi Arabia. Methods: The study involved a retrospective analysis of the records of patients with anterior uveitis, referred to the uveitis clinic in Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia, from 1999 to 2010. The cost-effectiveness of HLA-B27 testing was analyzed. Results: Among the 587 cases of uveitis, 335 (57.1%; mean age 37.56±12.82 years; 203 male and 132 female) cases were of anterior uveitis. All patients with anterior uveitis were investigated for HLA-B27 positivity. Idiopathic anterior uveitis was the most common (80%), followed by Fuchs heterochromic cyclitis (7.45%) and ankylosing spondylitis (3.8%). Only two patients were HLA-B27 positive. The cost-effectiveness of HLA-B27 testing was found to be 165,000 Saudi riyals (44,594 US dollars) per positive case. Conclusion: HLA-B27-related uveitis appears to be very rare in our part of the world. Idiopathic uveitis is the most common type of anterior uveitis. The cost-effectiveness of HLA-B27 testing is low for patients with anterior uveitis in the western region of Saudi Arabia. Keywords: HLA-B27, Saudi population, cost-effectiveness, idiopathic anterior uveitis, Fuchs heterochromic cyclitis, ankylosing spondylitis
format	article
author	Bawazeer AM Joharjy HI
author_facet	Bawazeer AM Joharjy HI
author_sort	Bawazeer AM
title	The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
title_short	The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
title_full	The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
title_fullStr	The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
title_full_unstemmed	The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study
title_sort	association of human leukocyte antigen b27 with anterior uveitis in patients from the western region of saudi arabia: a retrospective study
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6235ead769a24a2e85e1b9d952037065
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The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study

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