The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients

Background: Serum uric acid (SUA) has been found to be an independent risk factor for metabolic syndrome (MS). However, the reports pertaining to link between uric acid levels among the androgenic, non-androgenic (clinical) PCOS subjects are conflicting. Hence, it was aimed to determine incidence of...

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Autores principales:	Ranakishor Pelluri, M.Pharm, PDCR, Ph.D, Kongara Srikanth, Harika Paritala, Vamsi Ravi, Sri Pandu Mukharjee Kamma, Kishan Dravid Piduguralla, Unnam Venkateswarlu, Jalasuthram Subrahmanyam, Kiranmayee Bannaravuri, Thanmayee Thunga, Ragini Vemparala, Sruthi Doddapaneni, Naresh Avulamanda, Vathyam Sivani, Srinivasababu Puttagunta
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hyperuricemia Androgens Metabolic syndrome Poly cystic ovarian syndrome Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/623636d9c7f64565aae6d90edbcebf29
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spelling	oai:doaj.org-article:623636d9c7f64565aae6d90edbcebf292021-12-02T05:01:32ZThe role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients2213-398410.1016/j.cegh.2021.100910https://doaj.org/article/623636d9c7f64565aae6d90edbcebf292021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213398421002189https://doaj.org/toc/2213-3984Background: Serum uric acid (SUA) has been found to be an independent risk factor for metabolic syndrome (MS). However, the reports pertaining to link between uric acid levels among the androgenic, non-androgenic (clinical) PCOS subjects are conflicting. Hence, it was aimed to determine incidence of hyperuricmia and its association among the PCOS subjects. Methodology: A single centre hospital based cross-sectional study conducted in south India PCOS subjects during the March 2021 to August 2021. A total 80 subjects were recruited and were stratified into androgenic and non-androgenic PCOS with each of forty subjects in both groups. The incidence of hyper uricemica was found to be 66.25% (n = 53). Results: The mean and SD values of metabolic components such as HbA1C and FPG levels and triglycerides, low density lipoproteins and total cholesterol were showing statistically significant (p < 0.05) among the groups. The circulating sex hormone binding globulins (SHBG) are low in both groups. These levels are significantly low in androgenic PCOS subjects. The Total testosterone (TT), SHBG, HOMA-IR and LDL levels were positively correlated with both hyper and non-hyper uricemic groups and remaining parameters showed negative correlation. Conclusion: The incidence of hyperuricemia is high in PCOS subjects. The TT and SHBG, HOMA-IR and LDL levels were positively correlated with both hyper and non-hyper uricemic groups. HbA1C and FPG and FSI are negatively correlated among the groups.Ranakishor Pelluri, M.Pharm, PDCR, Ph.DKongara SrikanthHarika ParitalaVamsi RaviSri Pandu Mukharjee KammaKishan Dravid PidugurallaUnnam VenkateswarluJalasuthram SubrahmanyamKiranmayee BannaravuriThanmayee ThungaRagini VemparalaSruthi DoddapaneniNaresh AvulamandaVathyam SivaniSrinivasababu PuttaguntaElsevierarticleHyperuricemiaAndrogensMetabolic syndromePoly cystic ovarian syndromePublic aspects of medicineRA1-1270ENClinical Epidemiology and Global Health, Vol 12, Iss , Pp 100910- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hyperuricemia Androgens Metabolic syndrome Poly cystic ovarian syndrome Public aspects of medicine RA1-1270
spellingShingle	Hyperuricemia Androgens Metabolic syndrome Poly cystic ovarian syndrome Public aspects of medicine RA1-1270 Ranakishor Pelluri, M.Pharm, PDCR, Ph.D Kongara Srikanth Harika Paritala Vamsi Ravi Sri Pandu Mukharjee Kamma Kishan Dravid Piduguralla Unnam Venkateswarlu Jalasuthram Subrahmanyam Kiranmayee Bannaravuri Thanmayee Thunga Ragini Vemparala Sruthi Doddapaneni Naresh Avulamanda Vathyam Sivani Srinivasababu Puttagunta The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
description	Background: Serum uric acid (SUA) has been found to be an independent risk factor for metabolic syndrome (MS). However, the reports pertaining to link between uric acid levels among the androgenic, non-androgenic (clinical) PCOS subjects are conflicting. Hence, it was aimed to determine incidence of hyperuricmia and its association among the PCOS subjects. Methodology: A single centre hospital based cross-sectional study conducted in south India PCOS subjects during the March 2021 to August 2021. A total 80 subjects were recruited and were stratified into androgenic and non-androgenic PCOS with each of forty subjects in both groups. The incidence of hyper uricemica was found to be 66.25% (n = 53). Results: The mean and SD values of metabolic components such as HbA1C and FPG levels and triglycerides, low density lipoproteins and total cholesterol were showing statistically significant (p < 0.05) among the groups. The circulating sex hormone binding globulins (SHBG) are low in both groups. These levels are significantly low in androgenic PCOS subjects. The Total testosterone (TT), SHBG, HOMA-IR and LDL levels were positively correlated with both hyper and non-hyper uricemic groups and remaining parameters showed negative correlation. Conclusion: The incidence of hyperuricemia is high in PCOS subjects. The TT and SHBG, HOMA-IR and LDL levels were positively correlated with both hyper and non-hyper uricemic groups. HbA1C and FPG and FSI are negatively correlated among the groups.
format	article
author	Ranakishor Pelluri, M.Pharm, PDCR, Ph.D Kongara Srikanth Harika Paritala Vamsi Ravi Sri Pandu Mukharjee Kamma Kishan Dravid Piduguralla Unnam Venkateswarlu Jalasuthram Subrahmanyam Kiranmayee Bannaravuri Thanmayee Thunga Ragini Vemparala Sruthi Doddapaneni Naresh Avulamanda Vathyam Sivani Srinivasababu Puttagunta
author_facet	Ranakishor Pelluri, M.Pharm, PDCR, Ph.D Kongara Srikanth Harika Paritala Vamsi Ravi Sri Pandu Mukharjee Kamma Kishan Dravid Piduguralla Unnam Venkateswarlu Jalasuthram Subrahmanyam Kiranmayee Bannaravuri Thanmayee Thunga Ragini Vemparala Sruthi Doddapaneni Naresh Avulamanda Vathyam Sivani Srinivasababu Puttagunta
author_sort	Ranakishor Pelluri, M.Pharm, PDCR, Ph.D
title	The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
title_short	The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
title_full	The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
title_fullStr	The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
title_full_unstemmed	The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
title_sort	role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/623636d9c7f64565aae6d90edbcebf29
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The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients

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