Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness

Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness

ABSTRACT Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using th...

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Autores principales: Julien Mortier, Elisa Gayán, Ronald Van Eyken, Oscar Enrique Torres Montaguth, Ladan Khodaparast, Laleh Khodaparast, Bert Houben, Sebastien Carpentier, Frederic Rousseau, Joost Schymkowitz, Abram Aertsen
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
evolution
genetics
heat resistance
protein aggregates
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/623a01e2ab7646c0bffe2fbedf477587
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