RIP2 filament formation is required for NOD2 dependent NF-κB signalling

RIP2 filament formation is required for NOD2 dependent NF-κB signalling

Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Erika Pellegrini, Ambroise Desfosses, Arndt Wallmann, Wiebke Manuela Schulze, Kristina Rehbein, Philippe Mas, Luca Signor, Stephanie Gaudon, Grasilda Zenkeviciute, Michael Hons, Helene Malet, Irina Gutsche, Carsten Sachse, Guy Schoehn, Hartmut Oschkinat, Stephen Cusack
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/623d229f150f4a37a425004031c6872b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2.

Ejemplares similares