RIP2 filament formation is required for NOD2 dependent NF-κB signalling

Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation...

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Autores principales:	Erika Pellegrini, Ambroise Desfosses, Arndt Wallmann, Wiebke Manuela Schulze, Kristina Rehbein, Philippe Mas, Luca Signor, Stephanie Gaudon, Grasilda Zenkeviciute, Michael Hons, Helene Malet, Irina Gutsche, Carsten Sachse, Guy Schoehn, Hartmut Oschkinat, Stephen Cusack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/623d229f150f4a37a425004031c6872b
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spelling	oai:doaj.org-article:623d229f150f4a37a425004031c6872b2021-12-02T14:41:27ZRIP2 filament formation is required for NOD2 dependent NF-κB signalling10.1038/s41467-018-06451-32041-1723https://doaj.org/article/623d229f150f4a37a425004031c6872b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06451-3https://doaj.org/toc/2041-1723Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2.Erika PellegriniAmbroise DesfossesArndt WallmannWiebke Manuela SchulzeKristina RehbeinPhilippe MasLuca SignorStephanie GaudonGrasilda ZenkeviciuteMichael HonsHelene MaletIrina GutscheCarsten SachseGuy SchoehnHartmut OschkinatStephen CusackNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erika Pellegrini Ambroise Desfosses Arndt Wallmann Wiebke Manuela Schulze Kristina Rehbein Philippe Mas Luca Signor Stephanie Gaudon Grasilda Zenkeviciute Michael Hons Helene Malet Irina Gutsche Carsten Sachse Guy Schoehn Hartmut Oschkinat Stephen Cusack RIP2 filament formation is required for NOD2 dependent NF-κB signalling
description	Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2.
format	article
author	Erika Pellegrini Ambroise Desfosses Arndt Wallmann Wiebke Manuela Schulze Kristina Rehbein Philippe Mas Luca Signor Stephanie Gaudon Grasilda Zenkeviciute Michael Hons Helene Malet Irina Gutsche Carsten Sachse Guy Schoehn Hartmut Oschkinat Stephen Cusack
author_facet	Erika Pellegrini Ambroise Desfosses Arndt Wallmann Wiebke Manuela Schulze Kristina Rehbein Philippe Mas Luca Signor Stephanie Gaudon Grasilda Zenkeviciute Michael Hons Helene Malet Irina Gutsche Carsten Sachse Guy Schoehn Hartmut Oschkinat Stephen Cusack
author_sort	Erika Pellegrini
title	RIP2 filament formation is required for NOD2 dependent NF-κB signalling
title_short	RIP2 filament formation is required for NOD2 dependent NF-κB signalling
title_full	RIP2 filament formation is required for NOD2 dependent NF-κB signalling
title_fullStr	RIP2 filament formation is required for NOD2 dependent NF-κB signalling
title_full_unstemmed	RIP2 filament formation is required for NOD2 dependent NF-κB signalling
title_sort	rip2 filament formation is required for nod2 dependent nf-κb signalling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/623d229f150f4a37a425004031c6872b
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RIP2 filament formation is required for NOD2 dependent NF-κB signalling

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