Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

Abstract The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within the N-terminal domains of p85α previ...

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Autores principales: Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore, Deborah H. Anderson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/623db4a84b7e4de981307ebca5478389
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