Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer

Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional...

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Autores principales:	Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, Jongmin Woo, Youngsoo Kim, June Huh, Jong-Wan Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/623e4ab85e2d4530a2c6da57689692cc
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spelling	oai:doaj.org-article:623e4ab85e2d4530a2c6da57689692cc2021-12-02T15:39:19ZKetohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer10.1038/s41467-020-19263-12041-1723https://doaj.org/article/623e4ab85e2d4530a2c6da57689692cc2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19263-1https://doaj.org/toc/2041-1723Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional activity of the cell-adhesion molecule CDH1.Jiyoung KimJengmin KangYe-Lim KangJongmin WooYoungsoo KimJune HuhJong-Wan ParkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiyoung Kim Jengmin Kang Ye-Lim Kang Jongmin Woo Youngsoo Kim June Huh Jong-Wan Park Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
description	Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional activity of the cell-adhesion molecule CDH1.
format	article
author	Jiyoung Kim Jengmin Kang Ye-Lim Kang Jongmin Woo Youngsoo Kim June Huh Jong-Wan Park
author_facet	Jiyoung Kim Jengmin Kang Ye-Lim Kang Jongmin Woo Youngsoo Kim June Huh Jong-Wan Park
author_sort	Jiyoung Kim
title	Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
title_short	Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
title_full	Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
title_fullStr	Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
title_full_unstemmed	Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
title_sort	ketohexokinase-a acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/623e4ab85e2d4530a2c6da57689692cc
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Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer

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