Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the p...

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Autores principales:	Megan J. Bywater, Deborah L. Burkhart, Jasmin Straube, Arianna Sabò, Vera Pendino, James E. Hudson, Gregory A. Quaife-Ryan, Enzo R. Porrello, James Rae, Robert G. Parton, Theresia R. Kress, Bruno Amati, Trevor D. Littlewood, Gerard I. Evan, Catherine H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d895
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spelling	oai:doaj.org-article:6242a1a22a8f47f48a5d16c07381d8952021-12-02T17:33:13ZReactivation of Myc transcription in the mouse heart unlocks its proliferative capacity10.1038/s41467-020-15552-x2041-1723https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d8952020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15552-xhttps://doaj.org/toc/2041-1723Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the positive transcription elongation factor (P-TEFb).Megan J. BywaterDeborah L. BurkhartJasmin StraubeArianna SabòVera PendinoJames E. HudsonGregory A. Quaife-RyanEnzo R. PorrelloJames RaeRobert G. PartonTheresia R. KressBruno AmatiTrevor D. LittlewoodGerard I. EvanCatherine H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
description	Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the positive transcription elongation factor (P-TEFb).
format	article
author	Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson
author_facet	Megan J. Bywater Deborah L. Burkhart Jasmin Straube Arianna Sabò Vera Pendino James E. Hudson Gregory A. Quaife-Ryan Enzo R. Porrello James Rae Robert G. Parton Theresia R. Kress Bruno Amati Trevor D. Littlewood Gerard I. Evan Catherine H. Wilson
author_sort	Megan J. Bywater
title	Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
title_short	Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
title_full	Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
title_fullStr	Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
title_full_unstemmed	Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
title_sort	reactivation of myc transcription in the mouse heart unlocks its proliferative capacity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d895
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Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

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