Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and proliferative responses in cardiomyocytes depend on the p...
Saved in:
Main Authors: | Megan J. Bywater, Deborah L. Burkhart, Jasmin Straube, Arianna Sabò, Vera Pendino, James E. Hudson, Gregory A. Quaife-Ryan, Enzo R. Porrello, James Rae, Robert G. Parton, Theresia R. Kress, Bruno Amati, Trevor D. Littlewood, Gerard I. Evan, Catherine H. Wilson |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d895 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Unlocking the Ik instrumental case
by: Terrill Schrock
Published: (2014) -
Unlocking short read sequencing for metagenomics.
by: Sébastien Rodrigue, et al.
Published: (2010) -
Unlocking Household Electricity Consumption in Pakistan
by: Khuram Pervez Amber, et al.
Published: (2021) -
Unlocking the Constraints of Cyanobacterial Productivity: Acclimations Enabling Ultrafast Growth
by: Hans C. Bernstein, et al.
Published: (2016) -
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy.
by: Mauro Savino, et al.
Published: (2011)