Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

<h4>Background</h4>A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack,...

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Autores principales: Petter Brodin, Tadepally Lakshmikanth, Ramit Mehr, Maria H Johansson, Adil Doganay Duru, Adnane Achour, Mali Salmon-Divon, Klas Kärre, Petter Höglund, Sofia Johansson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/6242f9fce31942b8b6b1ccec4cbaf9fa
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