Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells

Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells

Sang-Eun Park,1,* Jaewon Lee,2,* Taeksu Lee,2 Saet-Byeol Bae,1 Byunghoon Kang,2 Yong-Min Huh,3 Sang-Wha Lee,1 Seungjoo Haam,2 1Department of Chemical and Biochemical Engineering, Gachon University, Gyeonggi-Do, Republic of Korea; 2Department of Chemical Engineering, Yonsei University, Seoul, Republ...

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Autores principales: Park SE, Lee J, Lee T, Bae SB, Kang B, Huh YM, Lee SW, Haam S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
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spelling oai:doaj.org-article:6243767b320b495fa54326d5c714098f2021-12-02T02:01:42ZComparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells1178-2013https://doaj.org/article/6243767b320b495fa54326d5c714098f2015-09-01T00:00:00Zhttps://www.dovepress.com/comparative-hyperthermia-effects-of-silicandashgold-nanoshells-with-di-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sang-Eun Park,1,* Jaewon Lee,2,* Taeksu Lee,2 Saet-Byeol Bae,1 Byunghoon Kang,2 Yong-Min Huh,3 Sang-Wha Lee,1 Seungjoo Haam,2 1Department of Chemical and Biochemical Engineering, Gachon University, Gyeonggi-Do, Republic of Korea; 2Department of Chemical Engineering, Yonsei University, Seoul, Republic of Korea; 3Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Silica–gold nanoshell (SGNS), which is a silica core surrounded by a gold layer, was synthesized by seed-mediated coalescence of gold clusters in an electroless plating solution. SGNS variations with different surface coverage of gold clusters were prepared by adjusting the amounts of gold salts in the presence of formaldehyde-reducing agents. Fully covered SGNS (f-SGNS) with connected gold clusters exhibited stronger intensity and more redshift of plasmon bands located around 820 nm than those of partially covered SGNS (p-SGNS) with disconnected gold clusters. Upon irradiation with near-infrared light (30 W/cm2, 700–800 nm), f-SGNS caused a larger hyperthermia effect, generating a large temperature change (ΔT =42°C), as compared to the relatively small temperature change (ΔT =24°C) caused by p-SGNS. The therapeutic antibody, Erbitux™ (ERB), was further conjugated to SGNS for specific tumor cell targeting. The f-ERB-SGNS showed excellent therapeutic efficacy based on the combined effect of both the therapeutic antibody and the full hyperthermia dose under near-infrared irradiation. Thus, SGNS with well-controlled surface morphology of gold shells may be applicable for near-infrared-induced hyperthermia therapy with tunable optical properties. Keywords: gold nanoshell, plasmon resonance, Erbitux, human epithelial cancer, hyperthermiaPark SELee JLee TBae SBKang BHuh YMLee SWHaam SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 261-271 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Park SE
Lee J
Lee T
Bae SB
Kang B
Huh YM
Lee SW
Haam S
Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
description Sang-Eun Park,1,* Jaewon Lee,2,* Taeksu Lee,2 Saet-Byeol Bae,1 Byunghoon Kang,2 Yong-Min Huh,3 Sang-Wha Lee,1 Seungjoo Haam,2 1Department of Chemical and Biochemical Engineering, Gachon University, Gyeonggi-Do, Republic of Korea; 2Department of Chemical Engineering, Yonsei University, Seoul, Republic of Korea; 3Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Silica–gold nanoshell (SGNS), which is a silica core surrounded by a gold layer, was synthesized by seed-mediated coalescence of gold clusters in an electroless plating solution. SGNS variations with different surface coverage of gold clusters were prepared by adjusting the amounts of gold salts in the presence of formaldehyde-reducing agents. Fully covered SGNS (f-SGNS) with connected gold clusters exhibited stronger intensity and more redshift of plasmon bands located around 820 nm than those of partially covered SGNS (p-SGNS) with disconnected gold clusters. Upon irradiation with near-infrared light (30 W/cm2, 700–800 nm), f-SGNS caused a larger hyperthermia effect, generating a large temperature change (ΔT =42°C), as compared to the relatively small temperature change (ΔT =24°C) caused by p-SGNS. The therapeutic antibody, Erbitux™ (ERB), was further conjugated to SGNS for specific tumor cell targeting. The f-ERB-SGNS showed excellent therapeutic efficacy based on the combined effect of both the therapeutic antibody and the full hyperthermia dose under near-infrared irradiation. Thus, SGNS with well-controlled surface morphology of gold shells may be applicable for near-infrared-induced hyperthermia therapy with tunable optical properties. Keywords: gold nanoshell, plasmon resonance, Erbitux, human epithelial cancer, hyperthermia
format article
author Park SE
Lee J
Lee T
Bae SB
Kang B
Huh YM
Lee SW
Haam S
author_facet Park SE
Lee J
Lee T
Bae SB
Kang B
Huh YM
Lee SW
Haam S
author_sort Park SE
title Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
title_short Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
title_full Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
title_fullStr Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
title_full_unstemmed Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
title_sort comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/6243767b320b495fa54326d5c714098f
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AT leet comparativehyperthermiaeffectsofsilicandashgoldnanoshellswithdifferentsurfacecoverageofgoldclustersonepithelialtumorcells
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