Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells

Summary: Prostaglandin E2 (PGE2) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE2 limits its clinical application. Improving the delivery of PGE2 specifically to the target organ with a prolonged release method is highly d...

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Autores principales:	Shang Chen, Haoyan Huang, Yue Liu, Chen Wang, Xiaoniao Chen, Yuqiao Chang, Yuhao Li, Zhikun Guo, Zhibo Han, Zhong-Chao Han, Qiang Zhao, Xiang-Mei Chen, Zongjin Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Drug delivery system Pathophysiology Cell biology Stem cells research Science Q
Acceso en línea:	https://doaj.org/article/6243c78afc474ff6b4bc551ca8403e5a
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spelling	oai:doaj.org-article:6243c78afc474ff6b4bc551ca8403e5a2021-11-20T05:08:48ZRenal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells2589-004210.1016/j.isci.2021.103243https://doaj.org/article/6243c78afc474ff6b4bc551ca8403e5a2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012116https://doaj.org/toc/2589-0042Summary: Prostaglandin E2 (PGE2) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE2 limits its clinical application. Improving the delivery of PGE2 specifically to the target organ with a prolonged release method is highly desirable. Taking advantage of the adequate space and proximity of the renal parenchyma, renal subcapsular delivery allows minimally invasive and effective delivery to the entire kidney. Here, we report that by covalently cross-linking it to a collagen matrix, PGE2 exhibits an adequate long-term presence in the kidney with extensive intraparenchymal penetration through renal subcapsular delivery and significantly improves kidney function. Sox9 cell lineage tracing with intravital microscopy revealed that PGE2 could activate the endogenous renal progenitor Sox9+ cells through the Yap signaling pathway. Our results highlight the prospects of utilizing renal subcapsular-based drug delivery and facilitate new applications of PGE2-releasing matrices for regenerative therapy.Shang ChenHaoyan HuangYue LiuChen WangXiaoniao ChenYuqiao ChangYuhao LiZhikun GuoZhibo HanZhong-Chao HanQiang ZhaoXiang-Mei ChenZongjin LiElsevierarticleDrug delivery systemPathophysiologyCell biologyStem cells researchScienceQENiScience, Vol 24, Iss 11, Pp 103243- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug delivery system Pathophysiology Cell biology Stem cells research Science Q
spellingShingle	Drug delivery system Pathophysiology Cell biology Stem cells research Science Q Shang Chen Haoyan Huang Yue Liu Chen Wang Xiaoniao Chen Yuqiao Chang Yuhao Li Zhikun Guo Zhibo Han Zhong-Chao Han Qiang Zhao Xiang-Mei Chen Zongjin Li Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
description	Summary: Prostaglandin E2 (PGE2) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE2 limits its clinical application. Improving the delivery of PGE2 specifically to the target organ with a prolonged release method is highly desirable. Taking advantage of the adequate space and proximity of the renal parenchyma, renal subcapsular delivery allows minimally invasive and effective delivery to the entire kidney. Here, we report that by covalently cross-linking it to a collagen matrix, PGE2 exhibits an adequate long-term presence in the kidney with extensive intraparenchymal penetration through renal subcapsular delivery and significantly improves kidney function. Sox9 cell lineage tracing with intravital microscopy revealed that PGE2 could activate the endogenous renal progenitor Sox9+ cells through the Yap signaling pathway. Our results highlight the prospects of utilizing renal subcapsular-based drug delivery and facilitate new applications of PGE2-releasing matrices for regenerative therapy.
format	article
author	Shang Chen Haoyan Huang Yue Liu Chen Wang Xiaoniao Chen Yuqiao Chang Yuhao Li Zhikun Guo Zhibo Han Zhong-Chao Han Qiang Zhao Xiang-Mei Chen Zongjin Li
author_facet	Shang Chen Haoyan Huang Yue Liu Chen Wang Xiaoniao Chen Yuqiao Chang Yuhao Li Zhikun Guo Zhibo Han Zhong-Chao Han Qiang Zhao Xiang-Mei Chen Zongjin Li
author_sort	Shang Chen
title	Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
title_short	Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
title_full	Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
title_fullStr	Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
title_full_unstemmed	Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells
title_sort	renal subcapsular delivery of pge2 promotes kidney repair by activating endogenous sox9+ stem cells
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6243c78afc474ff6b4bc551ca8403e5a
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Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells

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