Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice

Alcoholic liver disease is one of the most prevalent chronic diseases that causes high morbidity and mortality worldwide. This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice. BSPs were rich in oligopeptides (...

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Autores principales:	Jian Ren, Sijin Li, Chunli Song, Xiaohong Sun, Xiaolan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Alcalase Bioactive peptides Alcoholic liver injury Antioxidant Anti-inflammation Amino acid composition Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6244282fd4cb415e9619806f5accd032
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spelling	oai:doaj.org-article:6244282fd4cb415e9619806f5accd0322021-11-06T04:23:08ZBlack soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice1756-464610.1016/j.jff.2021.104828https://doaj.org/article/6244282fd4cb415e9619806f5accd0322021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004771https://doaj.org/toc/1756-4646Alcoholic liver disease is one of the most prevalent chronic diseases that causes high morbidity and mortality worldwide. This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice. BSPs were rich in oligopeptides (80%, w/w, <1,996 Da) and Lys. The median and high doses of BSPs (400–800 mg/kg·bw) decreased the levels of AST, ALT in serum. Only high dose of BSPs decreased the triglyceride content to normal level (P > 0.05). All treatments significantly (P < 0.01) reduced the creatinine level compared to the model group. The histopathological examination further confirmed the protective effect of BSPs. This protective effect is possibly attributed to the antioxidant and anti-inflammatory activities of BSPs due to the increased levels of GSH, SOD and CAT and decreased contents of MDA, IL-6 and IL-1β compared to those of model group.Jian RenSijin LiChunli SongXiaohong SunXiaolan LiuElsevierarticleAlcalaseBioactive peptidesAlcoholic liver injuryAntioxidantAnti-inflammationAmino acid compositionNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104828- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alcalase Bioactive peptides Alcoholic liver injury Antioxidant Anti-inflammation Amino acid composition Nutrition. Foods and food supply TX341-641
spellingShingle	Alcalase Bioactive peptides Alcoholic liver injury Antioxidant Anti-inflammation Amino acid composition Nutrition. Foods and food supply TX341-641 Jian Ren Sijin Li Chunli Song Xiaohong Sun Xiaolan Liu Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
description	Alcoholic liver disease is one of the most prevalent chronic diseases that causes high morbidity and mortality worldwide. This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice. BSPs were rich in oligopeptides (80%, w/w, <1,996 Da) and Lys. The median and high doses of BSPs (400–800 mg/kg·bw) decreased the levels of AST, ALT in serum. Only high dose of BSPs decreased the triglyceride content to normal level (P > 0.05). All treatments significantly (P < 0.01) reduced the creatinine level compared to the model group. The histopathological examination further confirmed the protective effect of BSPs. This protective effect is possibly attributed to the antioxidant and anti-inflammatory activities of BSPs due to the increased levels of GSH, SOD and CAT and decreased contents of MDA, IL-6 and IL-1β compared to those of model group.
format	article
author	Jian Ren Sijin Li Chunli Song Xiaohong Sun Xiaolan Liu
author_facet	Jian Ren Sijin Li Chunli Song Xiaohong Sun Xiaolan Liu
author_sort	Jian Ren
title	Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
title_short	Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
title_full	Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
title_fullStr	Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
title_full_unstemmed	Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
title_sort	black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6244282fd4cb415e9619806f5accd032
work_keys_str_mv	AT jianren blacksoybeanderivedpeptidesexertedprotectiveeffectagainstalcoholinducedliverinjuryinmice AT sijinli blacksoybeanderivedpeptidesexertedprotectiveeffectagainstalcoholinducedliverinjuryinmice AT chunlisong blacksoybeanderivedpeptidesexertedprotectiveeffectagainstalcoholinducedliverinjuryinmice AT xiaohongsun blacksoybeanderivedpeptidesexertedprotectiveeffectagainstalcoholinducedliverinjuryinmice AT xiaolanliu blacksoybeanderivedpeptidesexertedprotectiveeffectagainstalcoholinducedliverinjuryinmice
_version_	1718443919367208960

Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice

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