Growth hormone deficiency and the transition from pediatric to adult care

Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH) interruption/reinstitution after adult height achie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana Beatriz Winter Tavares, Paulo Ferrez Collett-Solberg
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Growth hormone Hypopituitarism Adolescent Metabolism Growth and development Therapeutics Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/62473a5645c9445fbe71aff35c1e8087
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62473a5645c9445fbe71aff35c1e8087
record_format	dspace
spelling	oai:doaj.org-article:62473a5645c9445fbe71aff35c1e80872021-11-06T04:13:17ZGrowth hormone deficiency and the transition from pediatric to adult care0021-755710.1016/j.jped.2021.02.007https://doaj.org/article/62473a5645c9445fbe71aff35c1e80872021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0021755721000541https://doaj.org/toc/0021-7557Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH) interruption/reinstitution after adult height achievement; (3) re-evaluation of somatrotropic axis; (4) management of rhGH reinstitution, when necessary. Source of data: Narrative review of the literature published at PubMed/MEDLINE until September 2020 including original and review articles, systematic reviews and meta-analyses. Synthesis of data: Growth hormone is crucial for the attainment of normal growth and for adequate somatic development, which does not end concomitantly with linear growth. Retesting adolescents who already meet the criteria that predict adult GHD with high specificity is not necessary. Patients with isolated GHD have a high likelihood of normal response to GH testing after puberty. Adolescents with confirmed GHD upon retesting should restart rhGH replacement and be monitored according to IGF-I levels, clinical parameters, and complementary exams. Conclusion: Patients with isolated idiopathic GHD in childhood are a special group who must be reevaluated for GHD as many of them have normal GH provocative tests upon retesting after puberty. Patients who confirm the persistence of GHD in the transition period should maintain rhGH replacement in order to reach an ideal peak bone mass, satisfactory body composition, lipid and glucose profiles, and quality of life.Ana Beatriz Winter TavaresPaulo Ferrez Collett-SolbergElsevierarticleGrowth hormoneHypopituitarismAdolescentMetabolismGrowth and developmentTherapeuticsPediatricsRJ1-570ENJornal de Pediatria, Vol 97, Iss 6, Pp 595-602 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Growth hormone Hypopituitarism Adolescent Metabolism Growth and development Therapeutics Pediatrics RJ1-570
spellingShingle	Growth hormone Hypopituitarism Adolescent Metabolism Growth and development Therapeutics Pediatrics RJ1-570 Ana Beatriz Winter Tavares Paulo Ferrez Collett-Solberg Growth hormone deficiency and the transition from pediatric to adult care
description	Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH) interruption/reinstitution after adult height achievement; (3) re-evaluation of somatrotropic axis; (4) management of rhGH reinstitution, when necessary. Source of data: Narrative review of the literature published at PubMed/MEDLINE until September 2020 including original and review articles, systematic reviews and meta-analyses. Synthesis of data: Growth hormone is crucial for the attainment of normal growth and for adequate somatic development, which does not end concomitantly with linear growth. Retesting adolescents who already meet the criteria that predict adult GHD with high specificity is not necessary. Patients with isolated GHD have a high likelihood of normal response to GH testing after puberty. Adolescents with confirmed GHD upon retesting should restart rhGH replacement and be monitored according to IGF-I levels, clinical parameters, and complementary exams. Conclusion: Patients with isolated idiopathic GHD in childhood are a special group who must be reevaluated for GHD as many of them have normal GH provocative tests upon retesting after puberty. Patients who confirm the persistence of GHD in the transition period should maintain rhGH replacement in order to reach an ideal peak bone mass, satisfactory body composition, lipid and glucose profiles, and quality of life.
format	article
author	Ana Beatriz Winter Tavares Paulo Ferrez Collett-Solberg
author_facet	Ana Beatriz Winter Tavares Paulo Ferrez Collett-Solberg
author_sort	Ana Beatriz Winter Tavares
title	Growth hormone deficiency and the transition from pediatric to adult care
title_short	Growth hormone deficiency and the transition from pediatric to adult care
title_full	Growth hormone deficiency and the transition from pediatric to adult care
title_fullStr	Growth hormone deficiency and the transition from pediatric to adult care
title_full_unstemmed	Growth hormone deficiency and the transition from pediatric to adult care
title_sort	growth hormone deficiency and the transition from pediatric to adult care
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/62473a5645c9445fbe71aff35c1e8087
work_keys_str_mv	AT anabeatrizwintertavares growthhormonedeficiencyandthetransitionfrompediatrictoadultcare AT pauloferrezcollettsolberg growthhormonedeficiencyandthetransitionfrompediatrictoadultcare
_version_	1718443919582167040

Growth hormone deficiency and the transition from pediatric to adult care

Ejemplares similares