Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)

Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)

Yon Ju Nam,1 Shin-Hye Kim2 1College of Health Science, Korea University, Seoul 02841, Korea; 2Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 01757, KoreaCorrespondence: Shin-Hye KimDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Inje Univ...

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Autores principales: Nam YJ, Kim SH
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
environmental pollutant
2-naphthol
2-hydroxyfluorene
environmental exposure
health survey
endocrine disruptors
Specialties of internal medicine
RC581-951
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spelling oai:doaj.org-article:624b5420d15c43ce88c8b61465b1481b2021-12-02T13:01:46ZAssociation of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)1178-7007https://doaj.org/article/624b5420d15c43ce88c8b61465b1481b2020-10-01T00:00:00Zhttps://www.dovepress.com/association-of-urinary-polycyclic-aromatic-hydrocarbons-and-diabetes-i-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yon Ju Nam,1 Shin-Hye Kim2 1College of Health Science, Korea University, Seoul 02841, Korea; 2Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 01757, KoreaCorrespondence: Shin-Hye KimDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine, 1342 Dongil-Ro, Nowon-Gu, Seoul 01757, KoreaTel +82-2-950-4812Fax +82-2-950-1246Email S2635@paik.ac.krPurpose: To investigate the associations between the urinary levels of polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus in Korean adults.Materials and Methods: We examined the data of 6478 participants aged ≥ 19 years from the Korean National Environmental Health Survey (KoNEHS) cycle 2 (2012– 2014). The urinary levels of 1-hydroxypyrene (1-OHP), 2-naphthol (2-NAP), 1-hydroxyphenathrene (1-OHPhe), and 2-hydroxyfluorene (2-OHFlu) were measured by gas chromatography-mass spectrometry. Diabetes mellitus was defined as a self-report of physician-diagnosed diabetes mellitus or the use of oral hypoglycemics or insulin. Analyses were adjusted for sex, age, body mass index, household income, alcohol consumption, physical activity, urinary creatinine and cotinine, menopausal status, and quartiles of all other PAHs.Results: The prevalence of diabetes was 6.5% in the study population. In men, the geometric means of the 2-NAP and 2-OHFlu levels were higher in participants with diabetes mellitus than in those without diabetes mellitus [4.11 vs 3.26 μg/L (P < 0.05) and 0.45 vs 0.40 μg/L (P < 0.05), respectively]. In women, the geometric mean of 2-NAP levels was also higher in participants with diabetes mellitus than in those without diabetes mellitus (1.81 vs 0.56 μg/L, P < 0.05), but there were no significant differences in geometric means for other PAHs. A higher odds ratio (OR) of diabetes was found in participants with the highest quartiles of urinary 2-NAP [OR 1.83, 95% confidence interval (CI) 1.29– 2.60] and 2-OHFlu (OR 1.81, 95% CI 1.10– 2.98) than in those with the lowest quartiles.Conclusion: The urinary 2-NAP and 2-OHFlu levels were associated with diabetes mellitus in Korean adults. Further studies are needed to determine a potential causal relationship between PAH exposure and diabetes mellitus and its underlying mechanism.Keywords: environmental pollutant, 2-naphthol, 2-hydroxyfluorene, environmental exposure, health survey, endocrine disruptorsNam YJKim SHDove Medical Pressarticleenvironmental pollutant2-naphthol2-hydroxyfluoreneenvironmental exposurehealth surveyendocrine disruptorsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3993-4003 (2020)
institution DOAJ
collection DOAJ
language EN
topic environmental pollutant
2-naphthol
2-hydroxyfluorene
environmental exposure
health survey
endocrine disruptors
Specialties of internal medicine
RC581-951
spellingShingle environmental pollutant
2-naphthol
2-hydroxyfluorene
environmental exposure
health survey
endocrine disruptors
Specialties of internal medicine
RC581-951
Nam YJ
Kim SH
Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
description Yon Ju Nam,1 Shin-Hye Kim2 1College of Health Science, Korea University, Seoul 02841, Korea; 2Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 01757, KoreaCorrespondence: Shin-Hye KimDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine, 1342 Dongil-Ro, Nowon-Gu, Seoul 01757, KoreaTel +82-2-950-4812Fax +82-2-950-1246Email S2635@paik.ac.krPurpose: To investigate the associations between the urinary levels of polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus in Korean adults.Materials and Methods: We examined the data of 6478 participants aged ≥ 19 years from the Korean National Environmental Health Survey (KoNEHS) cycle 2 (2012– 2014). The urinary levels of 1-hydroxypyrene (1-OHP), 2-naphthol (2-NAP), 1-hydroxyphenathrene (1-OHPhe), and 2-hydroxyfluorene (2-OHFlu) were measured by gas chromatography-mass spectrometry. Diabetes mellitus was defined as a self-report of physician-diagnosed diabetes mellitus or the use of oral hypoglycemics or insulin. Analyses were adjusted for sex, age, body mass index, household income, alcohol consumption, physical activity, urinary creatinine and cotinine, menopausal status, and quartiles of all other PAHs.Results: The prevalence of diabetes was 6.5% in the study population. In men, the geometric means of the 2-NAP and 2-OHFlu levels were higher in participants with diabetes mellitus than in those without diabetes mellitus [4.11 vs 3.26 μg/L (P < 0.05) and 0.45 vs 0.40 μg/L (P < 0.05), respectively]. In women, the geometric mean of 2-NAP levels was also higher in participants with diabetes mellitus than in those without diabetes mellitus (1.81 vs 0.56 μg/L, P < 0.05), but there were no significant differences in geometric means for other PAHs. A higher odds ratio (OR) of diabetes was found in participants with the highest quartiles of urinary 2-NAP [OR 1.83, 95% confidence interval (CI) 1.29– 2.60] and 2-OHFlu (OR 1.81, 95% CI 1.10– 2.98) than in those with the lowest quartiles.Conclusion: The urinary 2-NAP and 2-OHFlu levels were associated with diabetes mellitus in Korean adults. Further studies are needed to determine a potential causal relationship between PAH exposure and diabetes mellitus and its underlying mechanism.Keywords: environmental pollutant, 2-naphthol, 2-hydroxyfluorene, environmental exposure, health survey, endocrine disruptors
format article
author Nam YJ
Kim SH
author_facet Nam YJ
Kim SH
author_sort Nam YJ
title Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
title_short Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
title_full Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
title_fullStr Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
title_full_unstemmed Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012–2014)
title_sort association of urinary polycyclic aromatic hydrocarbons and diabetes in korean adults: data from the korean national environmental health survey cycle 2 (2012–2014)
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/624b5420d15c43ce88c8b61465b1481b
work_keys_str_mv AT namyj associationofurinarypolycyclicaromatichydrocarbonsanddiabetesinkoreanadultsdatafromthekoreannationalenvironmentalhealthsurveycycle22012ndash2014
AT kimsh associationofurinarypolycyclicaromatichydrocarbonsanddiabetesinkoreanadultsdatafromthekoreannationalenvironmentalhealthsurveycycle22012ndash2014
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