Plk1 overexpression induces chromosomal instability and suppresses tumor development

PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act as a tumor suppressor by perturbing mitotic progre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/624e442f805148c5bac60f63e764f010
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:624e442f805148c5bac60f63e764f010
record_format	dspace
spelling	oai:doaj.org-article:624e442f805148c5bac60f63e764f0102021-12-02T16:56:41ZPlk1 overexpression induces chromosomal instability and suppresses tumor development10.1038/s41467-018-05429-52041-1723https://doaj.org/article/624e442f805148c5bac60f63e764f0102018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05429-5https://doaj.org/toc/2041-1723PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act as a tumor suppressor by perturbing mitotic progression and cytokinesis.Guillermo de CárcerSharavan Vishaan VenkateswaranLorena SalgueiroAicha El BakkaliKalman SomogyiKonstantina RowaldPablo MontañésManuel SanclementeBeatriz EscobarAlba de MartinoNicholas McGranahanMarcos MalumbresRocío SotilloNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillermo de Cárcer Sharavan Vishaan Venkateswaran Lorena Salgueiro Aicha El Bakkali Kalman Somogyi Konstantina Rowald Pablo Montañés Manuel Sanclemente Beatriz Escobar Alba de Martino Nicholas McGranahan Marcos Malumbres Rocío Sotillo Plk1 overexpression induces chromosomal instability and suppresses tumor development
description	PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act as a tumor suppressor by perturbing mitotic progression and cytokinesis.
format	article
author	Guillermo de Cárcer Sharavan Vishaan Venkateswaran Lorena Salgueiro Aicha El Bakkali Kalman Somogyi Konstantina Rowald Pablo Montañés Manuel Sanclemente Beatriz Escobar Alba de Martino Nicholas McGranahan Marcos Malumbres Rocío Sotillo
author_facet	Guillermo de Cárcer Sharavan Vishaan Venkateswaran Lorena Salgueiro Aicha El Bakkali Kalman Somogyi Konstantina Rowald Pablo Montañés Manuel Sanclemente Beatriz Escobar Alba de Martino Nicholas McGranahan Marcos Malumbres Rocío Sotillo
author_sort	Guillermo de Cárcer
title	Plk1 overexpression induces chromosomal instability and suppresses tumor development
title_short	Plk1 overexpression induces chromosomal instability and suppresses tumor development
title_full	Plk1 overexpression induces chromosomal instability and suppresses tumor development
title_fullStr	Plk1 overexpression induces chromosomal instability and suppresses tumor development
title_full_unstemmed	Plk1 overexpression induces chromosomal instability and suppresses tumor development
title_sort	plk1 overexpression induces chromosomal instability and suppresses tumor development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/624e442f805148c5bac60f63e764f010
work_keys_str_mv	AT guillermodecarcer plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT sharavanvishaanvenkateswaran plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT lorenasalgueiro plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT aichaelbakkali plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT kalmansomogyi plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT konstantinarowald plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT pablomontanes plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT manuelsanclemente plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT beatrizescobar plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT albademartino plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT nicholasmcgranahan plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT marcosmalumbres plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment AT rociosotillo plk1overexpressioninduceschromosomalinstabilityandsuppressestumordevelopment
_version_	1718382741990408192

Plk1 overexpression induces chromosomal instability and suppresses tumor development

Ejemplares similares