Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population.
<h4>Background and purpose</h4>The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.<h4...
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2012
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oai:doaj.org-article:624f2bc91b7846fa86d8ffdc4bbd453f2021-11-18T07:28:35ZAssociation between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population.1932-620310.1371/journal.pone.0031086https://doaj.org/article/624f2bc91b7846fa86d8ffdc4bbd453f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22347434/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.<h4>Methods</h4>We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).<h4>Results</h4>Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.<h4>Conclusions</h4>These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.Irene Marta PredazziGiuseppe Danilo NorataLucia VecchioneKatia GarlaschelliFrancesca AmatiLiliana GrigoreLucia CutuliAngela PirilloSimona TramontanaFrancesco RomeoGiuseppe NovelliAlberico Luigi CatapanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31086 (2012) |
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DOAJ |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Irene Marta Predazzi Giuseppe Danilo Norata Lucia Vecchione Katia Garlaschelli Francesca Amati Liliana Grigore Lucia Cutuli Angela Pirillo Simona Tramontana Francesco Romeo Giuseppe Novelli Alberico Luigi Catapano Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| description |
<h4>Background and purpose</h4>The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.<h4>Methods</h4>We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).<h4>Results</h4>Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.<h4>Conclusions</h4>These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. |
| format |
article |
| author |
Irene Marta Predazzi Giuseppe Danilo Norata Lucia Vecchione Katia Garlaschelli Francesca Amati Liliana Grigore Lucia Cutuli Angela Pirillo Simona Tramontana Francesco Romeo Giuseppe Novelli Alberico Luigi Catapano |
| author_facet |
Irene Marta Predazzi Giuseppe Danilo Norata Lucia Vecchione Katia Garlaschelli Francesca Amati Liliana Grigore Lucia Cutuli Angela Pirillo Simona Tramontana Francesco Romeo Giuseppe Novelli Alberico Luigi Catapano |
| author_sort |
Irene Marta Predazzi |
| title |
Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| title_short |
Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| title_full |
Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| title_fullStr |
Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| title_full_unstemmed |
Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. |
| title_sort |
association between olr1 k167n snp and intima media thickness of the common carotid artery in the general population. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/624f2bc91b7846fa86d8ffdc4bbd453f |
| work_keys_str_mv |
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