Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane

Abstract The mammalian basilar membrane (BM) consists of two collagen-fiber layers responsible for the frequency-to-place tonotopic mapping in the cochlea, which together form a flat beam over at least part of the BM width. The mechanics of hearing in rodents such as gerbil pose a challenge to our u...

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Autores principales:	Santosh Kapuria, Charles R. Steele, Sunil Puria
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/624fa6b3d5a243aca678aff90915173d
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spelling	oai:doaj.org-article:624fa6b3d5a243aca678aff90915173d2021-12-02T15:06:23ZUnraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane10.1038/s41598-017-00114-x2045-2322https://doaj.org/article/624fa6b3d5a243aca678aff90915173d2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00114-xhttps://doaj.org/toc/2045-2322Abstract The mammalian basilar membrane (BM) consists of two collagen-fiber layers responsible for the frequency-to-place tonotopic mapping in the cochlea, which together form a flat beam over at least part of the BM width. The mechanics of hearing in rodents such as gerbil pose a challenge to our understanding of the cochlea, however, because for gerbil the two layers separate to form a pronounced arch over the remaining BM width. Moreover, the thickness and total width normally thought to determine the local stiffness, and tonotopic mapping in turn, change little along the cochlear length. A nonlinear analysis of a newly developed model, incorporating flat upper and arched lower fiber layers connected by ground substance, explains the initial plateau and subsequent quadratic increase found in measured stiffness vs. deflection curves under point loading, while for pressure loading the model accurately predicts the tonotopic mapping. The model also has applicability to understanding cochlear development and to interpreting evolutionary changes in mammalian hearing.Santosh KapuriaCharles R. SteeleSunil PuriaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Santosh Kapuria Charles R. Steele Sunil Puria Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
description	Abstract The mammalian basilar membrane (BM) consists of two collagen-fiber layers responsible for the frequency-to-place tonotopic mapping in the cochlea, which together form a flat beam over at least part of the BM width. The mechanics of hearing in rodents such as gerbil pose a challenge to our understanding of the cochlea, however, because for gerbil the two layers separate to form a pronounced arch over the remaining BM width. Moreover, the thickness and total width normally thought to determine the local stiffness, and tonotopic mapping in turn, change little along the cochlear length. A nonlinear analysis of a newly developed model, incorporating flat upper and arched lower fiber layers connected by ground substance, explains the initial plateau and subsequent quadratic increase found in measured stiffness vs. deflection curves under point loading, while for pressure loading the model accurately predicts the tonotopic mapping. The model also has applicability to understanding cochlear development and to interpreting evolutionary changes in mammalian hearing.
format	article
author	Santosh Kapuria Charles R. Steele Sunil Puria
author_facet	Santosh Kapuria Charles R. Steele Sunil Puria
author_sort	Santosh Kapuria
title	Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
title_short	Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
title_full	Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
title_fullStr	Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
title_full_unstemmed	Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
title_sort	unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/624fa6b3d5a243aca678aff90915173d
work_keys_str_mv	AT santoshkapuria unravelingthemysteryofhearingingerbilandotherrodentswithanarchbeammodelofthebasilarmembrane AT charlesrsteele unravelingthemysteryofhearingingerbilandotherrodentswithanarchbeammodelofthebasilarmembrane AT sunilpuria unravelingthemysteryofhearingingerbilandotherrodentswithanarchbeammodelofthebasilarmembrane
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Unraveling the mystery of hearing in gerbil and other rodents with an arch-beam model of the basilar membrane

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