A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract

Currently, a rise in incidence of polyethological inflammation of the upper respiratory tract mucosa paralleled by altered resident and transient microbiota displaying in many cases increased antibiotic resistance has been noted. Opportunistic microbes play a major role in developing inflammatory pr...

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Autores principales:	I. I. Ababii, L. A. Danilov, M. K. Maniuc, P. I. Ababii, S. S. Ghinda, M. G. Trofimciuc, M. P. Kostinov, A. V. Poddubikov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	tonsillitis microbiota antibiotic sensitivity streptococcus pneumococcus vaccination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/62512880f5b74b529ca9dbb03c043a74
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spelling	oai:doaj.org-article:62512880f5b74b529ca9dbb03c043a742021-11-22T07:09:54ZA role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract2220-76192313-739810.15789/2220-7619-ARO-809https://doaj.org/article/62512880f5b74b529ca9dbb03c043a742020-05-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/809https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Currently, a rise in incidence of polyethological inflammation of the upper respiratory tract mucosa paralleled by altered resident and transient microbiota displaying in many cases increased antibiotic resistance has been noted. Opportunistic microbes play a major role in developing inflammatory process in Pirogov–Waldeyer’s ring. An inflammatory process occurring in the tonsillar lymphatic tissue results in host systemic complications. Fighting against acute and chronic infections of the upper respiratory tract holds the main task in pediatric otorhinolaryngology, as they can consequently elicit the cardiovascular, genitourinary and musculoskeletal complications. The results of studies examining this issue remain very contradictory, which accounted for a need to conduct our study on the territory of Moldova featured with mixed climatic conditions. Here, we wanted to study a role of microbial factor in etiopathogenesis of chronic tonsillitis in children. Bacteriological microbiota data for superficial palatine tonsils were obtained form 608 children subdivided into 5 groups: group I — 333 children with compensated chronic tonsillitis; group II — 87 children with decompensated chronic tonsillitis; group III — 91 children with acute upper respiratory tract infections (comparison group); group IV — 48 children with acute upper respiratory tract infections treated with antibiotic therapy; group V — 49 apparently healthy children (control group). It was found that β-hemolytic streptococcus exerting high sensitivity to virtually all antibiotics groups was detected in 17.4% of children with acute tonsilar inflammatory processes and decompensated defense in the lymphatic pharyngeal ring compared to 3.5% in control group. Streptococcus pneumoniae was isolated in all study groups ranging within 4.8–21.7%, including 14% in apparently healthy children characterized by reduced antibiotics sensitivity. The data obtained suggest that sickly children with acute and chronic upper respiratory tract infections constitute a risk group for developing somatic diseases. The high incidence of Streptococcus pneumoniae indicates a need for performing immunoprophylaxis, use of therapeutic vaccination as a up-to-date, combined approach in treatment of such pediatric cohort.I. I. AbabiiL. A. DanilovM. K. ManiucP. I. AbabiiS. S. GhindaM. G. TrofimciucM. P. KostinovA. V. PoddubikovSankt-Peterburg : NIIÈM imeni Pasteraarticletonsillitismicrobiotaantibiotic sensitivitystreptococcuspneumococcusvaccinationInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 2, Pp 359-367 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	tonsillitis microbiota antibiotic sensitivity streptococcus pneumococcus vaccination Infectious and parasitic diseases RC109-216
spellingShingle	tonsillitis microbiota antibiotic sensitivity streptococcus pneumococcus vaccination Infectious and parasitic diseases RC109-216 I. I. Ababii L. A. Danilov M. K. Maniuc P. I. Ababii S. S. Ghinda M. G. Trofimciuc M. P. Kostinov A. V. Poddubikov A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
description	Currently, a rise in incidence of polyethological inflammation of the upper respiratory tract mucosa paralleled by altered resident and transient microbiota displaying in many cases increased antibiotic resistance has been noted. Opportunistic microbes play a major role in developing inflammatory process in Pirogov–Waldeyer’s ring. An inflammatory process occurring in the tonsillar lymphatic tissue results in host systemic complications. Fighting against acute and chronic infections of the upper respiratory tract holds the main task in pediatric otorhinolaryngology, as they can consequently elicit the cardiovascular, genitourinary and musculoskeletal complications. The results of studies examining this issue remain very contradictory, which accounted for a need to conduct our study on the territory of Moldova featured with mixed climatic conditions. Here, we wanted to study a role of microbial factor in etiopathogenesis of chronic tonsillitis in children. Bacteriological microbiota data for superficial palatine tonsils were obtained form 608 children subdivided into 5 groups: group I — 333 children with compensated chronic tonsillitis; group II — 87 children with decompensated chronic tonsillitis; group III — 91 children with acute upper respiratory tract infections (comparison group); group IV — 48 children with acute upper respiratory tract infections treated with antibiotic therapy; group V — 49 apparently healthy children (control group). It was found that β-hemolytic streptococcus exerting high sensitivity to virtually all antibiotics groups was detected in 17.4% of children with acute tonsilar inflammatory processes and decompensated defense in the lymphatic pharyngeal ring compared to 3.5% in control group. Streptococcus pneumoniae was isolated in all study groups ranging within 4.8–21.7%, including 14% in apparently healthy children characterized by reduced antibiotics sensitivity. The data obtained suggest that sickly children with acute and chronic upper respiratory tract infections constitute a risk group for developing somatic diseases. The high incidence of Streptococcus pneumoniae indicates a need for performing immunoprophylaxis, use of therapeutic vaccination as a up-to-date, combined approach in treatment of such pediatric cohort.
format	article
author	I. I. Ababii L. A. Danilov M. K. Maniuc P. I. Ababii S. S. Ghinda M. G. Trofimciuc M. P. Kostinov A. V. Poddubikov
author_facet	I. I. Ababii L. A. Danilov M. K. Maniuc P. I. Ababii S. S. Ghinda M. G. Trofimciuc M. P. Kostinov A. V. Poddubikov
author_sort	I. I. Ababii
title	A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
title_short	A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
title_full	A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
title_fullStr	A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
title_full_unstemmed	A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
title_sort	role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/62512880f5b74b529ca9dbb03c043a74
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A role of oropharyngeal microbiota in developing acute and chronic diseases of the upper respiratory tract

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