The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence

Emerging studies suggest that extracellular vesicles (EVs) mediating intercellular communication in the tumor microenvironment (TME) play a key role in driving cancer progression. Tumor-derived small EVs or exosomes (TEX) enriched in immunosuppressive proteins or in microRNAs targeting suppressive p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Theresa L. Whiteside
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor-derived exosomes (TEX) extracellular vesicles (EVs) adenosinergic pathway immune suppression tumor microenvironment (TME) Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6254270982e641faa047dd7003faec5a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6254270982e641faa047dd7003faec5a
record_format	dspace
spelling	oai:doaj.org-article:6254270982e641faa047dd7003faec5a2021-11-25T17:10:52ZThe Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence10.3390/cells101130542073-4409https://doaj.org/article/6254270982e641faa047dd7003faec5a2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3054https://doaj.org/toc/2073-4409Emerging studies suggest that extracellular vesicles (EVs) mediating intercellular communication in the tumor microenvironment (TME) play a key role in driving cancer progression. Tumor-derived small EVs or exosomes (TEX) enriched in immunosuppressive proteins or in microRNAs targeting suppressive pathways in recipient cells contribute to reprogramming the TME into a cancer-promoting milieu. The adenosinergic pathway is an acknowledged major contributor to tumor-induced immune suppression. TEX carry the components of this pathway and utilize ATP to produce adenosine (ADO). TEX-associated ADO emerges as a key factor in the suppression of T cell responses to therapy. Here, the significance of the ADO pathway in TEX is discussed as a highly effective mechanism of cancer-driven immune cell suppression and of resistance to immune therapies.Theresa L. WhitesideMDPI AGarticletumor-derived exosomes (TEX)extracellular vesicles (EVs)adenosinergic pathwayimmune suppressiontumor microenvironment (TME)Biology (General)QH301-705.5ENCells, Vol 10, Iss 3054, p 3054 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor-derived exosomes (TEX) extracellular vesicles (EVs) adenosinergic pathway immune suppression tumor microenvironment (TME) Biology (General) QH301-705.5
spellingShingle	tumor-derived exosomes (TEX) extracellular vesicles (EVs) adenosinergic pathway immune suppression tumor microenvironment (TME) Biology (General) QH301-705.5 Theresa L. Whiteside The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
description	Emerging studies suggest that extracellular vesicles (EVs) mediating intercellular communication in the tumor microenvironment (TME) play a key role in driving cancer progression. Tumor-derived small EVs or exosomes (TEX) enriched in immunosuppressive proteins or in microRNAs targeting suppressive pathways in recipient cells contribute to reprogramming the TME into a cancer-promoting milieu. The adenosinergic pathway is an acknowledged major contributor to tumor-induced immune suppression. TEX carry the components of this pathway and utilize ATP to produce adenosine (ADO). TEX-associated ADO emerges as a key factor in the suppression of T cell responses to therapy. Here, the significance of the ADO pathway in TEX is discussed as a highly effective mechanism of cancer-driven immune cell suppression and of resistance to immune therapies.
format	article
author	Theresa L. Whiteside
author_facet	Theresa L. Whiteside
author_sort	Theresa L. Whiteside
title	The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
title_short	The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
title_full	The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
title_fullStr	The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
title_full_unstemmed	The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence
title_sort	role of tumor-derived exosomes (tex) in shaping anti-tumor immune competence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6254270982e641faa047dd7003faec5a
work_keys_str_mv	AT theresalwhiteside theroleoftumorderivedexosomestexinshapingantitumorimmunecompetence AT theresalwhiteside roleoftumorderivedexosomestexinshapingantitumorimmunecompetence
_version_	1718412653601226752

The Role of Tumor-Derived Exosomes (TEX) in Shaping Anti-Tumor Immune Competence

Ejemplares similares