YAP regulates cell mechanics by controlling focal adhesion assembly

The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.

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Autores principales:	Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6257312755974ce381c3c1ab209da290
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spelling	oai:doaj.org-article:6257312755974ce381c3c1ab209da2902021-12-02T14:42:35ZYAP regulates cell mechanics by controlling focal adhesion assembly10.1038/ncomms153212041-1723https://doaj.org/article/6257312755974ce381c3c1ab209da2902017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15321https://doaj.org/toc/2041-1723The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.Giorgia NardoneJorge Oliver-De La CruzJan VrbskyCecilia MartiniJan PribylPetr SkládalMartin PešlGuido CaluoriStefania PagliariFabiana MartinoZuzana MaceckovaMarian HajduchAndres Sanz-GarciaNicola Maria PugnoGorazd Bernard StokinGiancarlo ForteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giorgia Nardone Jorge Oliver-De La Cruz Jan Vrbsky Cecilia Martini Jan Pribyl Petr Skládal Martin Pešl Guido Caluori Stefania Pagliari Fabiana Martino Zuzana Maceckova Marian Hajduch Andres Sanz-Garcia Nicola Maria Pugno Gorazd Bernard Stokin Giancarlo Forte YAP regulates cell mechanics by controlling focal adhesion assembly
description	The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.
format	article
author	Giorgia Nardone Jorge Oliver-De La Cruz Jan Vrbsky Cecilia Martini Jan Pribyl Petr Skládal Martin Pešl Guido Caluori Stefania Pagliari Fabiana Martino Zuzana Maceckova Marian Hajduch Andres Sanz-Garcia Nicola Maria Pugno Gorazd Bernard Stokin Giancarlo Forte
author_facet	Giorgia Nardone Jorge Oliver-De La Cruz Jan Vrbsky Cecilia Martini Jan Pribyl Petr Skládal Martin Pešl Guido Caluori Stefania Pagliari Fabiana Martino Zuzana Maceckova Marian Hajduch Andres Sanz-Garcia Nicola Maria Pugno Gorazd Bernard Stokin Giancarlo Forte
author_sort	Giorgia Nardone
title	YAP regulates cell mechanics by controlling focal adhesion assembly
title_short	YAP regulates cell mechanics by controlling focal adhesion assembly
title_full	YAP regulates cell mechanics by controlling focal adhesion assembly
title_fullStr	YAP regulates cell mechanics by controlling focal adhesion assembly
title_full_unstemmed	YAP regulates cell mechanics by controlling focal adhesion assembly
title_sort	yap regulates cell mechanics by controlling focal adhesion assembly
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6257312755974ce381c3c1ab209da290
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YAP regulates cell mechanics by controlling focal adhesion assembly

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