Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neurons of the developing spinal cord.

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Autores principales:	Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/625df354e8904d6d8d48ca404cd12312
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spelling	oai:doaj.org-article:625df354e8904d6d8d48ca404cd123122021-12-02T16:58:17ZQuantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis10.1038/s41467-019-10734-82041-1723https://doaj.org/article/625df354e8904d6d8d48ca404cd123122019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10734-8https://doaj.org/toc/2041-1723The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neurons of the developing spinal cord.Cerys S. ManningVeronica BigaJames BoydJochen KursaweBodvar YmissonDavid G. SpillerChristopher M. SandersonTobias GallaMagnus RattrayNancy PapalopuluNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cerys S. Manning Veronica Biga James Boyd Jochen Kursawe Bodvar Ymisson David G. Spiller Christopher M. Sanderson Tobias Galla Magnus Rattray Nancy Papalopulu Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
description	The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neurons of the developing spinal cord.
format	article
author	Cerys S. Manning Veronica Biga James Boyd Jochen Kursawe Bodvar Ymisson David G. Spiller Christopher M. Sanderson Tobias Galla Magnus Rattray Nancy Papalopulu
author_facet	Cerys S. Manning Veronica Biga James Boyd Jochen Kursawe Bodvar Ymisson David G. Spiller Christopher M. Sanderson Tobias Galla Magnus Rattray Nancy Papalopulu
author_sort	Cerys S. Manning
title	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
title_short	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
title_full	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
title_fullStr	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
title_full_unstemmed	Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
title_sort	quantitative single-cell live imaging links hes5 dynamics with cell-state and fate in murine neurogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/625df354e8904d6d8d48ca404cd12312
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Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

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