Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms

Japanese encephalitis (JEV) is a well-known arthropod-borne pathogen that is considered an emerging pathogen that causes brain infections. It has a high mortality rate, and morbidity is responsible for 10,000 to 15,000 deaths each year. Nerve cell entry and central nervous system infection are where...

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Autor principal:	Faiz Abdulaziz Alfaiz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Viral Infection Immunological drug targets Japanese encephalitis NS1 protein E protein Fusion inhibitors Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/625ebecfe4a14c35a27b8ceed71f1d1f
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spelling	oai:doaj.org-article:625ebecfe4a14c35a27b8ceed71f1d1f2021-11-14T04:30:53ZStructural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms1018-364710.1016/j.jksus.2021.101681https://doaj.org/article/625ebecfe4a14c35a27b8ceed71f1d1f2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003438https://doaj.org/toc/1018-3647Japanese encephalitis (JEV) is a well-known arthropod-borne pathogen that is considered an emerging pathogen that causes brain infections. It has a high mortality rate, and morbidity is responsible for 10,000 to 15,000 deaths each year. Nerve cell entry and central nervous system infection are where the virus begins its neuronal invasion phase. It weakens the body's natural defences and sets in motion the neurotrophic effects. There is no effective treatment or drug to combat the inhibition; however, there are some vaccine candidates on the market. JEV drug targets and their functional analysis determine which drugs are most effective in inhibiting the invasion and hijacking of host immune cells. Viral entry-level drug targets have been shown to be the starting point for the immunological vaccine, and their inhibitory profiles are discussed in this review for the entry-level drug targets. Replication of a virus begins with viral entry, and the process continues with infection, maintenance and dissemination. Among the proteins, non-structural and structural proteins are known for their function, and blocking those will result in inhibition, and thus the drug targets of JEV are discussed. This review discusses the JEV overview of drug targets, infection, and immunity to help with the future of JEV drug development.Faiz Abdulaziz AlfaizElsevierarticleViral InfectionImmunological drug targetsJapanese encephalitisNS1 proteinE proteinFusion inhibitorsScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101681- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Viral Infection Immunological drug targets Japanese encephalitis NS1 protein E protein Fusion inhibitors Science (General) Q1-390
spellingShingle	Viral Infection Immunological drug targets Japanese encephalitis NS1 protein E protein Fusion inhibitors Science (General) Q1-390 Faiz Abdulaziz Alfaiz Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
description	Japanese encephalitis (JEV) is a well-known arthropod-borne pathogen that is considered an emerging pathogen that causes brain infections. It has a high mortality rate, and morbidity is responsible for 10,000 to 15,000 deaths each year. Nerve cell entry and central nervous system infection are where the virus begins its neuronal invasion phase. It weakens the body's natural defences and sets in motion the neurotrophic effects. There is no effective treatment or drug to combat the inhibition; however, there are some vaccine candidates on the market. JEV drug targets and their functional analysis determine which drugs are most effective in inhibiting the invasion and hijacking of host immune cells. Viral entry-level drug targets have been shown to be the starting point for the immunological vaccine, and their inhibitory profiles are discussed in this review for the entry-level drug targets. Replication of a virus begins with viral entry, and the process continues with infection, maintenance and dissemination. Among the proteins, non-structural and structural proteins are known for their function, and blocking those will result in inhibition, and thus the drug targets of JEV are discussed. This review discusses the JEV overview of drug targets, infection, and immunity to help with the future of JEV drug development.
format	article
author	Faiz Abdulaziz Alfaiz
author_facet	Faiz Abdulaziz Alfaiz
author_sort	Faiz Abdulaziz Alfaiz
title	Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
title_short	Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
title_full	Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
title_fullStr	Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
title_full_unstemmed	Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms
title_sort	structural and functional analysis of japanese encephalitis virus drug targets in focus on immune evasion mechanisms
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/625ebecfe4a14c35a27b8ceed71f1d1f
work_keys_str_mv	AT faizabdulazizalfaiz structuralandfunctionalanalysisofjapaneseencephalitisvirusdrugtargetsinfocusonimmuneevasionmechanisms
_version_	1718429959357202432

Structural and functional analysis of Japanese encephalitis virus drug targets in focus on immune evasion mechanisms

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