Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases
Abstract Macroautophagic recycling of dysfunctional mitochondria, known as mitophagy, is essential for mitochondrial homeostasis and cell viability. Accumulation of defective mitochondria and impaired mitophagy have been widely implicated in many neurodegenerative diseases, and loss-of-function muta...
Guardado en:
Autores principales: | Elissa Tjahjono, Jingqi Pei, Alexey V. Revtovich, Terri-Jeanne E. Liu, Alisha Swadi, Maria C. Hancu, Joe G. Tolar, Natalia V. Kirienko |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/62602521c7314afcacbfc9edc4abc37a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Virulence
por: Daniel R. Kirienko, et al.
Publicado: (2016) -
Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
por: Ashu Johri, et al.
Publicado: (2021) -
Identification and validation of a novel anti-virulent that binds to pyoverdine and inhibits its function
por: Xu Wang, et al.
Publicado: (2020) -
Cellular proteostasis decline in human senescence
por: Karli Montague-Cardoso
Publicado: (2021) -
Impaired proteostasis contributes to renal tubular dysgenesis.
por: Rita Machado de Oliveira, et al.
Publicado: (2011)