Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases

Abstract Macroautophagic recycling of dysfunctional mitochondria, known as mitophagy, is essential for mitochondrial homeostasis and cell viability. Accumulation of defective mitochondria and impaired mitophagy have been widely implicated in many neurodegenerative diseases, and loss-of-function muta...

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Autores principales: Elissa Tjahjono, Jingqi Pei, Alexey V. Revtovich, Terri-Jeanne E. Liu, Alisha Swadi, Maria C. Hancu, Joe G. Tolar, Natalia V. Kirienko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/62602521c7314afcacbfc9edc4abc37a
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