Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

The transient receptor potential channel member 2 (TRPM2) ion channel has a function in redox-dependent signaling. Here the authors present the cryo-EM structures of zebrafish TRPM2 in the ligand-free form, with Ca2+ and both ADP-ribose/Ca2+ and observe two-fold symmetric quaternary structure rearra...

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Autores principales:	Ying Yin, Mengyu Wu, Allen L. Hsu, William F. Borschel, Mario J. Borgnia, Gabriel C. Lander, Seok-Yong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6260631b549d4c0287f9fa8aff10adbc
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spelling	oai:doaj.org-article:6260631b549d4c0287f9fa8aff10adbc2021-12-02T17:33:22ZVisualizing structural transitions of ligand-dependent gating of the TRPM2 channel10.1038/s41467-019-11733-52041-1723https://doaj.org/article/6260631b549d4c0287f9fa8aff10adbc2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11733-5https://doaj.org/toc/2041-1723The transient receptor potential channel member 2 (TRPM2) ion channel has a function in redox-dependent signaling. Here the authors present the cryo-EM structures of zebrafish TRPM2 in the ligand-free form, with Ca2+ and both ADP-ribose/Ca2+ and observe two-fold symmetric quaternary structure rearrangements in the ligand-bound structures that likely represent intermediate gating states.Ying YinMengyu WuAllen L. HsuWilliam F. BorschelMario J. BorgniaGabriel C. LanderSeok-Yong LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Yin Mengyu Wu Allen L. Hsu William F. Borschel Mario J. Borgnia Gabriel C. Lander Seok-Yong Lee Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
description	The transient receptor potential channel member 2 (TRPM2) ion channel has a function in redox-dependent signaling. Here the authors present the cryo-EM structures of zebrafish TRPM2 in the ligand-free form, with Ca2+ and both ADP-ribose/Ca2+ and observe two-fold symmetric quaternary structure rearrangements in the ligand-bound structures that likely represent intermediate gating states.
format	article
author	Ying Yin Mengyu Wu Allen L. Hsu William F. Borschel Mario J. Borgnia Gabriel C. Lander Seok-Yong Lee
author_facet	Ying Yin Mengyu Wu Allen L. Hsu William F. Borschel Mario J. Borgnia Gabriel C. Lander Seok-Yong Lee
author_sort	Ying Yin
title	Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
title_short	Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
title_full	Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
title_fullStr	Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
title_full_unstemmed	Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
title_sort	visualizing structural transitions of ligand-dependent gating of the trpm2 channel
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6260631b549d4c0287f9fa8aff10adbc
work_keys_str_mv	AT yingyin visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT mengyuwu visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT allenlhsu visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT williamfborschel visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT mariojborgnia visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT gabrielclander visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel AT seokyonglee visualizingstructuraltransitionsofliganddependentgatingofthetrpm2channel
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Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

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