Laxative-induced rhabdomyolysis

Alfonso Merante1, Pietro Gareri2,3, Norma Maria Marigliano2, Salvatore De Fazio2, Elvira Bonacci1, Carlo Torchia1, Gaetano Russo1, Pasquale Lacroce1, Roberto Lacava3, Alberto Castagna3, Giovambattista De Sarro2, Giovanni Ruotolo11Geriatrist, Geriatric Unit “Pugliese-Ciaccio” Hosp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alfonso Merante, Pietro Gareri, Norma Maria Marigliano, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	rhabdomyolysis laxatives elderly over-the-counter drugs Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/6261b9897e00445698a93d08bf569e44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6261b9897e00445698a93d08bf569e44
record_format	dspace
spelling	oai:doaj.org-article:6261b9897e00445698a93d08bf569e442021-12-02T06:54:52ZLaxative-induced rhabdomyolysis1178-1998https://doaj.org/article/6261b9897e00445698a93d08bf569e442010-03-01T00:00:00Zhttps://www.dovepress.com/laxative-induced-rhabdomyolysis-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alfonso Merante1, Pietro Gareri2,3, Norma Maria Marigliano2, Salvatore De Fazio2, Elvira Bonacci1, Carlo Torchia1, Gaetano Russo1, Pasquale Lacroce1, Roberto Lacava3, Alberto Castagna3, Giovambattista De Sarro2, Giovanni Ruotolo11Geriatrist, Geriatric Unit “Pugliese-Ciaccio” Hospital, Catanzaro, Italy; 2Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy; 3Geriatrist, Operative Unit Elderly Health Care, Catanzaro, ItalyAbstract: The present study describes a case of laxative-induced rhabdomyolysis in an elderly patient. An 87-year-old woman was hospitalized for the onset of confusion, tremors, an inability to walk, and a fever that she had been experiencing for 36 hours. She often took high dosages of lactulose and sorbitol syrup as a laxative (about 70 g/day). During her physical examination, the patient was confused, drowsy, and she presented hyposthenia in her upper and lower limbs, symmetric and diffuse moderate hyporeflexia, and her temperature was 37.8°C. Laboratory tests revealed severe hyponatremia with hypokalemia, hypocalcemia, hypochloremia, and metabolic alkalosis. Moreover, rhabdomyolysis markers were found. The correction of hydroelectrolytic imbalances with saline, potassium and sodium chlorure, calcium gluconate was the first treatment. During her hospitalization the patient presented acute delirium, treated with haloperidol and prometazine chloridrate intramuscularly. She was discharged 12 days later, after resolution of symptoms, and normalized laboratory tests. Over-the-counter drugs such as laxatives are usually not considered dangerous; on the other hand, they may cause serum electrolytic imbalance and rhabdomyolysis. A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and their secondary effects may be fatal.Keywords: rhabdomyolysis, laxatives, elderly, over-the-counter drugsAlfonso MerantePietro GareriNorma Maria Mariglianoet alDove Medical Pressarticlerhabdomyolysislaxativeselderlyover-the-counter drugsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 71-73 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	rhabdomyolysis laxatives elderly over-the-counter drugs Geriatrics RC952-954.6
spellingShingle	rhabdomyolysis laxatives elderly over-the-counter drugs Geriatrics RC952-954.6 Alfonso Merante Pietro Gareri Norma Maria Marigliano et al Laxative-induced rhabdomyolysis
description	Alfonso Merante1, Pietro Gareri2,3, Norma Maria Marigliano2, Salvatore De Fazio2, Elvira Bonacci1, Carlo Torchia1, Gaetano Russo1, Pasquale Lacroce1, Roberto Lacava3, Alberto Castagna3, Giovambattista De Sarro2, Giovanni Ruotolo11Geriatrist, Geriatric Unit “Pugliese-Ciaccio” Hospital, Catanzaro, Italy; 2Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy; 3Geriatrist, Operative Unit Elderly Health Care, Catanzaro, ItalyAbstract: The present study describes a case of laxative-induced rhabdomyolysis in an elderly patient. An 87-year-old woman was hospitalized for the onset of confusion, tremors, an inability to walk, and a fever that she had been experiencing for 36 hours. She often took high dosages of lactulose and sorbitol syrup as a laxative (about 70 g/day). During her physical examination, the patient was confused, drowsy, and she presented hyposthenia in her upper and lower limbs, symmetric and diffuse moderate hyporeflexia, and her temperature was 37.8°C. Laboratory tests revealed severe hyponatremia with hypokalemia, hypocalcemia, hypochloremia, and metabolic alkalosis. Moreover, rhabdomyolysis markers were found. The correction of hydroelectrolytic imbalances with saline, potassium and sodium chlorure, calcium gluconate was the first treatment. During her hospitalization the patient presented acute delirium, treated with haloperidol and prometazine chloridrate intramuscularly. She was discharged 12 days later, after resolution of symptoms, and normalized laboratory tests. Over-the-counter drugs such as laxatives are usually not considered dangerous; on the other hand, they may cause serum electrolytic imbalance and rhabdomyolysis. A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and their secondary effects may be fatal.Keywords: rhabdomyolysis, laxatives, elderly, over-the-counter drugs
format	article
author	Alfonso Merante Pietro Gareri Norma Maria Marigliano et al
author_facet	Alfonso Merante Pietro Gareri Norma Maria Marigliano et al
author_sort	Alfonso Merante
title	Laxative-induced rhabdomyolysis
title_short	Laxative-induced rhabdomyolysis
title_full	Laxative-induced rhabdomyolysis
title_fullStr	Laxative-induced rhabdomyolysis
title_full_unstemmed	Laxative-induced rhabdomyolysis
title_sort	laxative-induced rhabdomyolysis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/6261b9897e00445698a93d08bf569e44
work_keys_str_mv	AT alfonsomerante laxativeinducedrhabdomyolysis AT pietrogareri laxativeinducedrhabdomyolysis AT normamariamarigliano laxativeinducedrhabdomyolysis AT etal laxativeinducedrhabdomyolysis
_version_	1718399693521682432

Laxative-induced rhabdomyolysis

Ejemplares similares