Optical functionalization of human Class A orphan G-protein-coupled receptors

G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ligand identity and downstream signaling.

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Autores principales:	Maurizio Morri, Inmaculada Sanchez-Romero, Alexandra-Madelaine Tichy, Stephanie Kainrath, Elliot J. Gerrard, Priscila P. Hirschfeld, Jan Schwarz, Harald Janovjak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6261fce9394843269dc20223e9a3d059
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spelling	oai:doaj.org-article:6261fce9394843269dc20223e9a3d0592021-12-02T15:34:05ZOptical functionalization of human Class A orphan G-protein-coupled receptors10.1038/s41467-018-04342-12041-1723https://doaj.org/article/6261fce9394843269dc20223e9a3d0592018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04342-1https://doaj.org/toc/2041-1723G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ligand identity and downstream signaling.Maurizio MorriInmaculada Sanchez-RomeroAlexandra-Madelaine TichyStephanie KainrathElliot J. GerrardPriscila P. HirschfeldJan SchwarzHarald JanovjakNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maurizio Morri Inmaculada Sanchez-Romero Alexandra-Madelaine Tichy Stephanie Kainrath Elliot J. Gerrard Priscila P. Hirschfeld Jan Schwarz Harald Janovjak Optical functionalization of human Class A orphan G-protein-coupled receptors
description	G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ligand identity and downstream signaling.
format	article
author	Maurizio Morri Inmaculada Sanchez-Romero Alexandra-Madelaine Tichy Stephanie Kainrath Elliot J. Gerrard Priscila P. Hirschfeld Jan Schwarz Harald Janovjak
author_facet	Maurizio Morri Inmaculada Sanchez-Romero Alexandra-Madelaine Tichy Stephanie Kainrath Elliot J. Gerrard Priscila P. Hirschfeld Jan Schwarz Harald Janovjak
author_sort	Maurizio Morri
title	Optical functionalization of human Class A orphan G-protein-coupled receptors
title_short	Optical functionalization of human Class A orphan G-protein-coupled receptors
title_full	Optical functionalization of human Class A orphan G-protein-coupled receptors
title_fullStr	Optical functionalization of human Class A orphan G-protein-coupled receptors
title_full_unstemmed	Optical functionalization of human Class A orphan G-protein-coupled receptors
title_sort	optical functionalization of human class a orphan g-protein-coupled receptors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6261fce9394843269dc20223e9a3d059
work_keys_str_mv	AT mauriziomorri opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT inmaculadasanchezromero opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT alexandramadelainetichy opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT stephaniekainrath opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT elliotjgerrard opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT priscilaphirschfeld opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT janschwarz opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors AT haraldjanovjak opticalfunctionalizationofhumanclassaorphangproteincoupledreceptors
_version_	1718386903097540608

Optical functionalization of human Class A orphan G-protein-coupled receptors

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