COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS

Objective: To compare the in-vitro efficacy of vancomycin, linezolid and daptomycin against Methicillin Resistant Staphylococcus Aureus (MRSA). Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Army Medical College Rawalpindi, from Jan 2012 to Jul 20...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Mushtaq Gill, Javaid Usman, Fatima Kaleem, Afreenish Hassan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	daptomycin efficacy linezolid methicillin resistant staphylococcus aureus Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/62640bf2f765450da045537cbd8534b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62640bf2f765450da045537cbd8534b5
record_format	dspace
spelling	oai:doaj.org-article:62640bf2f765450da045537cbd8534b52021-11-09T02:56:32ZCOMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS0030-96482411-8842https://doaj.org/article/62640bf2f765450da045537cbd8534b52019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3400/2375https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the in-vitro efficacy of vancomycin, linezolid and daptomycin against Methicillin Resistant Staphylococcus Aureus (MRSA). Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Army Medical College Rawalpindi, from Jan 2012 to Jul 2012. Methodology: Staphylococcus Aureus isolated from routine clinical specimens were subjected to Modified Kirby Bauer disc diffusion method for detection of MRSA as per Clinical and Laboratory Standards Institute guidelines. Minimum Inhibitory Concentration (MIC) of vancomycin, linezolid and daptomycin for each of 50 non-duplicate isolates of MRSA was determined by Etest, as per manufecturer’s instructions (AB Biodisk, Solna, Sweden). The minimum concentration of the three antimicrobials required to inhibit fifty percent (MIC50) and ninety percent (MIC90) of the isolates were calculated by cumulative percentage. Results: The Etest results revealed MIC90 of vancomycin, linezolid and daptomycin as 2μg/ml, 1μg/ml, and 0.5μg/ml respectively. Daptomycin was found to have better in vitro efficacy based upon its lowest MIC90 value. Conclusion: Compared to vancomycin and linezolid, daptomycin has a better in vitro efficacy against MRSA. However adoption of proper antiseptic measures and a judicious use of antimicrobial agents were the strongest weapons that we can develop against the multi-drug resistant organisms like MRSA.Maria Mushtaq GillJavaid UsmanFatima KaleemAfreenish HassanArmy Medical College Rawalpindiarticledaptomycinefficacylinezolidmethicillin resistantstaphylococcus aureusMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 986-991 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	daptomycin efficacy linezolid methicillin resistant staphylococcus aureus Medicine R Medicine (General) R5-920
spellingShingle	daptomycin efficacy linezolid methicillin resistant staphylococcus aureus Medicine R Medicine (General) R5-920 Maria Mushtaq Gill Javaid Usman Fatima Kaleem Afreenish Hassan COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
description	Objective: To compare the in-vitro efficacy of vancomycin, linezolid and daptomycin against Methicillin Resistant Staphylococcus Aureus (MRSA). Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Army Medical College Rawalpindi, from Jan 2012 to Jul 2012. Methodology: Staphylococcus Aureus isolated from routine clinical specimens were subjected to Modified Kirby Bauer disc diffusion method for detection of MRSA as per Clinical and Laboratory Standards Institute guidelines. Minimum Inhibitory Concentration (MIC) of vancomycin, linezolid and daptomycin for each of 50 non-duplicate isolates of MRSA was determined by Etest, as per manufecturer’s instructions (AB Biodisk, Solna, Sweden). The minimum concentration of the three antimicrobials required to inhibit fifty percent (MIC50) and ninety percent (MIC90) of the isolates were calculated by cumulative percentage. Results: The Etest results revealed MIC90 of vancomycin, linezolid and daptomycin as 2μg/ml, 1μg/ml, and 0.5μg/ml respectively. Daptomycin was found to have better in vitro efficacy based upon its lowest MIC90 value. Conclusion: Compared to vancomycin and linezolid, daptomycin has a better in vitro efficacy against MRSA. However adoption of proper antiseptic measures and a judicious use of antimicrobial agents were the strongest weapons that we can develop against the multi-drug resistant organisms like MRSA.
format	article
author	Maria Mushtaq Gill Javaid Usman Fatima Kaleem Afreenish Hassan
author_facet	Maria Mushtaq Gill Javaid Usman Fatima Kaleem Afreenish Hassan
author_sort	Maria Mushtaq Gill
title	COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
title_short	COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
title_full	COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
title_fullStr	COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
title_full_unstemmed	COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
title_sort	comparison of in-vitro efficacy of vancomycin, linezolid and daptomycin against methicillin resistant staphylococcus aureus
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/62640bf2f765450da045537cbd8534b5
work_keys_str_mv	AT mariamushtaqgill comparisonofinvitroefficacyofvancomycinlinezolidanddaptomycinagainstmethicillinresistantstaphylococcusaureus AT javaidusman comparisonofinvitroefficacyofvancomycinlinezolidanddaptomycinagainstmethicillinresistantstaphylococcusaureus AT fatimakaleem comparisonofinvitroefficacyofvancomycinlinezolidanddaptomycinagainstmethicillinresistantstaphylococcusaureus AT afreenishhassan comparisonofinvitroefficacyofvancomycinlinezolidanddaptomycinagainstmethicillinresistantstaphylococcusaureus
_version_	1718441388469649408

COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS

Ejemplares similares