Reversible insulin resistance helps Bactrian camels survive fasting

Abstract Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expressi...

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Autores principales:	Fucheng Guo, Rendalai Si, Quanyun Li, Le Hai, Li Yi, Jing He, Liang Ming, Rimutu Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6264c8dfafc54410a9952fc35d4d6e4b
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spelling	oai:doaj.org-article:6264c8dfafc54410a9952fc35d4d6e4b2021-12-02T18:48:23ZReversible insulin resistance helps Bactrian camels survive fasting10.1038/s41598-021-98234-y2045-2322https://doaj.org/article/6264c8dfafc54410a9952fc35d4d6e4b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98234-yhttps://doaj.org/toc/2045-2322Abstract Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was significantly downregulated in the fore hump and hind hump during the fasting period. In addition, there was no difference in serum insulin levels among the three stages. However, the serum leptin and adiponectin levels decreased significantly during fasting. Additionally, insulin tolerance tests during the three stages showed that camels were insensitive to insulin during fasting. Further study of the serum metabolites showed that serum branched-chain and aromatic amino acid levels increased during the fasting period. Finally, analysis of microbial diversity in camel faeces at different stages showed that during the fasting period, the proportion of Firmicutes and Actinobacteria increased, while that of Bacteroides and the butyrate-producing bacterium Roseburia decreased. The results of this study show that fasting is accompanied by changes in the activation of insulin pathways in various camel tissues, normal insulin levels, and increased lipolysis and insulin resistance, which return to normal after eating.Fucheng GuoRendalai SiQuanyun LiLe HaiLi YiJing HeLiang MingRimutu JiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fucheng Guo Rendalai Si Quanyun Li Le Hai Li Yi Jing He Liang Ming Rimutu Ji Reversible insulin resistance helps Bactrian camels survive fasting
description	Abstract Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was significantly downregulated in the fore hump and hind hump during the fasting period. In addition, there was no difference in serum insulin levels among the three stages. However, the serum leptin and adiponectin levels decreased significantly during fasting. Additionally, insulin tolerance tests during the three stages showed that camels were insensitive to insulin during fasting. Further study of the serum metabolites showed that serum branched-chain and aromatic amino acid levels increased during the fasting period. Finally, analysis of microbial diversity in camel faeces at different stages showed that during the fasting period, the proportion of Firmicutes and Actinobacteria increased, while that of Bacteroides and the butyrate-producing bacterium Roseburia decreased. The results of this study show that fasting is accompanied by changes in the activation of insulin pathways in various camel tissues, normal insulin levels, and increased lipolysis and insulin resistance, which return to normal after eating.
format	article
author	Fucheng Guo Rendalai Si Quanyun Li Le Hai Li Yi Jing He Liang Ming Rimutu Ji
author_facet	Fucheng Guo Rendalai Si Quanyun Li Le Hai Li Yi Jing He Liang Ming Rimutu Ji
author_sort	Fucheng Guo
title	Reversible insulin resistance helps Bactrian camels survive fasting
title_short	Reversible insulin resistance helps Bactrian camels survive fasting
title_full	Reversible insulin resistance helps Bactrian camels survive fasting
title_fullStr	Reversible insulin resistance helps Bactrian camels survive fasting
title_full_unstemmed	Reversible insulin resistance helps Bactrian camels survive fasting
title_sort	reversible insulin resistance helps bactrian camels survive fasting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6264c8dfafc54410a9952fc35d4d6e4b
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Reversible insulin resistance helps Bactrian camels survive fasting

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