Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-kappaB, thereby blocking the production of pro-inflammatory cytokines. We have solved the cryst...

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Detalles Bibliográficos
Autores principales: Stephen C Graham, Mohammad W Bahar, Samantha Cooray, Ron A-J Chen, Daniel M Whalen, Nicola G A Abrescia, David Alderton, Raymond J Owens, David I Stuart, Geoffrey L Smith, Jonathan M Grimes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/6265b3759e864642a5c56c4d5cc20027
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