Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.

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Autores principales:	Hideaki Yano, Ning-Sheng Cai, Min Xu, Ravi Kumar Verma, William Rea, Alexander F. Hoffman, Lei Shi, Jonathan A. Javitch, Antonello Bonci, Sergi Ferré
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6269903e50c3459fb1f298160b9253b7
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spelling	oai:doaj.org-article:6269903e50c3459fb1f298160b9253b72021-12-02T17:33:03ZGs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor10.1038/s41467-017-02606-w2041-1723https://doaj.org/article/6269903e50c3459fb1f298160b9253b72018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02606-whttps://doaj.org/toc/2041-1723D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.Hideaki YanoNing-Sheng CaiMin XuRavi Kumar VermaWilliam ReaAlexander F. HoffmanLei ShiJonathan A. JavitchAntonello BonciSergi FerréNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hideaki Yano Ning-Sheng Cai Min Xu Ravi Kumar Verma William Rea Alexander F. Hoffman Lei Shi Jonathan A. Javitch Antonello Bonci Sergi Ferré Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
description	D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
format	article
author	Hideaki Yano Ning-Sheng Cai Min Xu Ravi Kumar Verma William Rea Alexander F. Hoffman Lei Shi Jonathan A. Javitch Antonello Bonci Sergi Ferré
author_facet	Hideaki Yano Ning-Sheng Cai Min Xu Ravi Kumar Verma William Rea Alexander F. Hoffman Lei Shi Jonathan A. Javitch Antonello Bonci Sergi Ferré
author_sort	Hideaki Yano
title	Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
title_short	Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
title_full	Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
title_fullStr	Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
title_full_unstemmed	Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
title_sort	gs- versus golf-dependent functional selectivity mediated by the dopamine d1 receptor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6269903e50c3459fb1f298160b9253b7
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Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

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