Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature

Abstract Background Primary lymphoma of the prostate is an exceedingly rare disease, with diffuse large B-cell lymphoma being the most common known subtype in a small number of reported cases. Due to its low prevalence, there has been a chronic lack of targeted diagnostic guidelines and treatment pr...

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Autores principales:	Mengwei Ren, Yanli Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Prostate Diffuse large B-cell lymphoma Lower urinary tract symptoms Case report Medicine R
Acceso en línea:	https://doaj.org/article/626caff1107c4823897d6ba757f3e2ab
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spelling	oai:doaj.org-article:626caff1107c4823897d6ba757f3e2ab2021-11-08T11:13:58ZPrimary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature10.1186/s13256-021-03143-31752-1947https://doaj.org/article/626caff1107c4823897d6ba757f3e2ab2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03143-3https://doaj.org/toc/1752-1947Abstract Background Primary lymphoma of the prostate is an exceedingly rare disease, with diffuse large B-cell lymphoma being the most common known subtype in a small number of reported cases. Due to its low prevalence, there has been a chronic lack of targeted diagnostic guidelines and treatment procedures. Case presentation In this article, we report a case of primary diffuse large B-cell lymphoma of the prostate in a 70-year-old Asian man who presented with symptoms of urinary tract obstruction. Histological and immunocytochemical studies of transurethral biopsy of the prostate showed diffuse large B-cell lymphoma. The patient was managed by a combination of eight courses of chemotherapy with a regimen including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and radiotherapy. Post-chemotherapy computed tomography scans showed complete remission. He remained disease free, until now, 15 months after the end of therapy. We also reviewed and analyzed relevant literature to illustrate the diagnosis, treatment, and prognosis of this disease. Conclusion Diffuse large B-cell non-Hodgkin’s lymphoma originating in the prostate is a rare and highly aggressive disease that lacks specificity in its clinical presentation and is easily misdiagnosed. This disease should be considered clinically in patients with significant prostate enlargement and insignificant prostate-specific antigen elevation. The diagnosis can be clarified with a prostate puncture biopsy. Chemotherapy is the main treatment for patients and may be supplemented with surgical treatment and radiotherapy.Mengwei RenYanli LiuBMCarticleProstateDiffuse large B-cell lymphomaLower urinary tract symptomsCase reportMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostate Diffuse large B-cell lymphoma Lower urinary tract symptoms Case report Medicine R
spellingShingle	Prostate Diffuse large B-cell lymphoma Lower urinary tract symptoms Case report Medicine R Mengwei Ren Yanli Liu Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
description	Abstract Background Primary lymphoma of the prostate is an exceedingly rare disease, with diffuse large B-cell lymphoma being the most common known subtype in a small number of reported cases. Due to its low prevalence, there has been a chronic lack of targeted diagnostic guidelines and treatment procedures. Case presentation In this article, we report a case of primary diffuse large B-cell lymphoma of the prostate in a 70-year-old Asian man who presented with symptoms of urinary tract obstruction. Histological and immunocytochemical studies of transurethral biopsy of the prostate showed diffuse large B-cell lymphoma. The patient was managed by a combination of eight courses of chemotherapy with a regimen including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and radiotherapy. Post-chemotherapy computed tomography scans showed complete remission. He remained disease free, until now, 15 months after the end of therapy. We also reviewed and analyzed relevant literature to illustrate the diagnosis, treatment, and prognosis of this disease. Conclusion Diffuse large B-cell non-Hodgkin’s lymphoma originating in the prostate is a rare and highly aggressive disease that lacks specificity in its clinical presentation and is easily misdiagnosed. This disease should be considered clinically in patients with significant prostate enlargement and insignificant prostate-specific antigen elevation. The diagnosis can be clarified with a prostate puncture biopsy. Chemotherapy is the main treatment for patients and may be supplemented with surgical treatment and radiotherapy.
format	article
author	Mengwei Ren Yanli Liu
author_facet	Mengwei Ren Yanli Liu
author_sort	Mengwei Ren
title	Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
title_short	Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
title_full	Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
title_fullStr	Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
title_full_unstemmed	Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature
title_sort	primary diffuse large b-cell lymphoma of the prostate: a case report and review of the literature
publisher	BMC
publishDate	2021
url	https://doaj.org/article/626caff1107c4823897d6ba757f3e2ab
work_keys_str_mv	AT mengweiren primarydiffuselargebcelllymphomaoftheprostateacasereportandreviewoftheliterature AT yanliliu primarydiffuselargebcelllymphomaoftheprostateacasereportandreviewoftheliterature
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Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature

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