Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG int...

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Autores principales:	Yuhsuke Ohmi, Wataru Ise, Akira Harazono, Daisuke Takakura, Hidehiro Fukuyama, Yoshihiro Baba, Masashi Narazaki, Hirofumi Shoda, Nobunori Takahashi, Yuki Ohkawa, Shuting Ji, Fumihiro Sugiyama, Keishi Fujio, Atsushi Kumanogoh, Kazuhiko Yamamoto, Nana Kawasaki, Tomohiro Kurosaki, Yoshimasa Takahashi, Koichi Furukawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/626de5323ebb454892d4e77327d0fdec
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spelling	oai:doaj.org-article:626de5323ebb454892d4e77327d0fdec2021-12-02T17:32:07ZSialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis10.1038/ncomms112052041-1723https://doaj.org/article/626de5323ebb454892d4e77327d0fdec2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11205https://doaj.org/toc/2041-1723Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice.Yuhsuke OhmiWataru IseAkira HarazonoDaisuke TakakuraHidehiro FukuyamaYoshihiro BabaMasashi NarazakiHirofumi ShodaNobunori TakahashiYuki OhkawaShuting JiFumihiro SugiyamaKeishi FujioAtsushi KumanogohKazuhiko YamamotoNana KawasakiTomohiro KurosakiYoshimasa TakahashiKoichi FurukawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuhsuke Ohmi Wataru Ise Akira Harazono Daisuke Takakura Hidehiro Fukuyama Yoshihiro Baba Masashi Narazaki Hirofumi Shoda Nobunori Takahashi Yuki Ohkawa Shuting Ji Fumihiro Sugiyama Keishi Fujio Atsushi Kumanogoh Kazuhiko Yamamoto Nana Kawasaki Tomohiro Kurosaki Yoshimasa Takahashi Koichi Furukawa Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
description	Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice.
format	article
author	Yuhsuke Ohmi Wataru Ise Akira Harazono Daisuke Takakura Hidehiro Fukuyama Yoshihiro Baba Masashi Narazaki Hirofumi Shoda Nobunori Takahashi Yuki Ohkawa Shuting Ji Fumihiro Sugiyama Keishi Fujio Atsushi Kumanogoh Kazuhiko Yamamoto Nana Kawasaki Tomohiro Kurosaki Yoshimasa Takahashi Koichi Furukawa
author_facet	Yuhsuke Ohmi Wataru Ise Akira Harazono Daisuke Takakura Hidehiro Fukuyama Yoshihiro Baba Masashi Narazaki Hirofumi Shoda Nobunori Takahashi Yuki Ohkawa Shuting Ji Fumihiro Sugiyama Keishi Fujio Atsushi Kumanogoh Kazuhiko Yamamoto Nana Kawasaki Tomohiro Kurosaki Yoshimasa Takahashi Koichi Furukawa
author_sort	Yuhsuke Ohmi
title	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
title_short	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
title_full	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
title_fullStr	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
title_full_unstemmed	Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
title_sort	sialylation converts arthritogenic igg into inhibitors of collagen-induced arthritis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/626de5323ebb454892d4e77327d0fdec
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Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

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