A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in diverse cellular activities. Here the authors show a synthetic BRET-based transgene expression system that allows pulsatile and quantitative activation of gene expression both in live cells and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting Li, Xianjun Chen, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye, Yi Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62711c0e7c3940c19d1557b65bceb217
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62711c0e7c3940c19d1557b65bceb217
record_format	dspace
spelling	oai:doaj.org-article:62711c0e7c3940c19d1557b65bceb2172021-12-02T10:48:27ZA synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice10.1038/s41467-021-20913-12041-1723https://doaj.org/article/62711c0e7c3940c19d1557b65bceb2172021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20913-1https://doaj.org/toc/2041-1723Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in diverse cellular activities. Here the authors show a synthetic BRET-based transgene expression system that allows pulsatile and quantitative activation of gene expression both in live cells and in vivo.Ting LiXianjun ChenYajie QianJiawei ShaoXie LiShuning LiuLinyong ZhuYuzheng ZhaoHaifeng YeYi YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Li Xianjun Chen Yajie Qian Jiawei Shao Xie Li Shuning Liu Linyong Zhu Yuzheng Zhao Haifeng Ye Yi Yang A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
description	Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in diverse cellular activities. Here the authors show a synthetic BRET-based transgene expression system that allows pulsatile and quantitative activation of gene expression both in live cells and in vivo.
format	article
author	Ting Li Xianjun Chen Yajie Qian Jiawei Shao Xie Li Shuning Liu Linyong Zhu Yuzheng Zhao Haifeng Ye Yi Yang
author_facet	Ting Li Xianjun Chen Yajie Qian Jiawei Shao Xie Li Shuning Liu Linyong Zhu Yuzheng Zhao Haifeng Ye Yi Yang
author_sort	Ting Li
title	A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
title_short	A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
title_full	A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
title_fullStr	A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
title_full_unstemmed	A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
title_sort	synthetic bret-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62711c0e7c3940c19d1557b65bceb217
work_keys_str_mv	AT tingli asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT xianjunchen asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yajieqian asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT jiaweishao asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT xieli asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT shuningliu asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT linyongzhu asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yuzhengzhao asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT haifengye asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yiyang asyntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT tingli syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT xianjunchen syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yajieqian syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT jiaweishao syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT xieli syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT shuningliu syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT linyongzhu syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yuzhengzhao syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT haifengye syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice AT yiyang syntheticbretbasedoptogeneticdeviceforpulsatiletransgeneexpressionenablingglucosehomeostasisinmice
_version_	1718396650412572672

A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

Ejemplares similares