APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.

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Autores principales:	Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6279c67f0fd74c15a58ff8bbebdd96ab
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spelling	oai:doaj.org-article:6279c67f0fd74c15a58ff8bbebdd96ab2021-12-02T16:49:15ZAPOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids10.1038/s41467-020-19264-02041-1723https://doaj.org/article/6279c67f0fd74c15a58ff8bbebdd96ab2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19264-0https://doaj.org/toc/2041-1723APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.Jing ZhaoYuan FuYu YamazakiYingxue RenMary D. DavisChia-Chen LiuWenyan LuXue WangKai ChenYesesri CherukuriLin JiaYuka A. MartensLucy JobFrancis ShueThanh Thanh NguyenSteven G. YounkinNeill R. Graff-RadfordZbigniew K. WszolekDavid A. BrafmanYan W. AsmannNilüfer Ertekin-TanerTakahisa KanekiyoGuojun BuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Zhao Yuan Fu Yu Yamazaki Yingxue Ren Mary D. Davis Chia-Chen Liu Wenyan Lu Xue Wang Kai Chen Yesesri Cherukuri Lin Jia Yuka A. Martens Lucy Job Francis Shue Thanh Thanh Nguyen Steven G. Younkin Neill R. Graff-Radford Zbigniew K. Wszolek David A. Brafman Yan W. Asmann Nilüfer Ertekin-Taner Takahisa Kanekiyo Guojun Bu APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
description	APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.
format	article
author	Jing Zhao Yuan Fu Yu Yamazaki Yingxue Ren Mary D. Davis Chia-Chen Liu Wenyan Lu Xue Wang Kai Chen Yesesri Cherukuri Lin Jia Yuka A. Martens Lucy Job Francis Shue Thanh Thanh Nguyen Steven G. Younkin Neill R. Graff-Radford Zbigniew K. Wszolek David A. Brafman Yan W. Asmann Nilüfer Ertekin-Taner Takahisa Kanekiyo Guojun Bu
author_facet	Jing Zhao Yuan Fu Yu Yamazaki Yingxue Ren Mary D. Davis Chia-Chen Liu Wenyan Lu Xue Wang Kai Chen Yesesri Cherukuri Lin Jia Yuka A. Martens Lucy Job Francis Shue Thanh Thanh Nguyen Steven G. Younkin Neill R. Graff-Radford Zbigniew K. Wszolek David A. Brafman Yan W. Asmann Nilüfer Ertekin-Taner Takahisa Kanekiyo Guojun Bu
author_sort	Jing Zhao
title	APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
title_short	APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
title_full	APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
title_fullStr	APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
title_full_unstemmed	APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
title_sort	apoe4 exacerbates synapse loss and neurodegeneration in alzheimer’s disease patient ipsc-derived cerebral organoids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6279c67f0fd74c15a58ff8bbebdd96ab
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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

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