Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions

The bridged medium-sized ring bicyclo[m.n.2] family of natural products are commonly found but difficult to synthesize efficiently. Here the authors present a cascade reaction to form the carbon skeleton, via a [3+2] cycloaddition of a captured azavinyl carbene intermediate.

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Autores principales:	Bao-Long Hou, Jonathan J. Wong, Na Lv, Yong-Qiang Wang, K. N. Houk, Chuang-Chuang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/627bce7cc54a425fbd80ac8222aa7cd9
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spelling	oai:doaj.org-article:627bce7cc54a425fbd80ac8222aa7cd92021-12-02T16:37:39ZFacile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions10.1038/s41467-021-25513-72041-1723https://doaj.org/article/627bce7cc54a425fbd80ac8222aa7cd92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25513-7https://doaj.org/toc/2041-1723The bridged medium-sized ring bicyclo[m.n.2] family of natural products are commonly found but difficult to synthesize efficiently. Here the authors present a cascade reaction to form the carbon skeleton, via a [3+2] cycloaddition of a captured azavinyl carbene intermediate.Bao-Long HouJonathan J. WongNa LvYong-Qiang WangK. N. HoukChuang-Chuang LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bao-Long Hou Jonathan J. Wong Na Lv Yong-Qiang Wang K. N. Houk Chuang-Chuang Li Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
description	The bridged medium-sized ring bicyclo[m.n.2] family of natural products are commonly found but difficult to synthesize efficiently. Here the authors present a cascade reaction to form the carbon skeleton, via a [3+2] cycloaddition of a captured azavinyl carbene intermediate.
format	article
author	Bao-Long Hou Jonathan J. Wong Na Lv Yong-Qiang Wang K. N. Houk Chuang-Chuang Li
author_facet	Bao-Long Hou Jonathan J. Wong Na Lv Yong-Qiang Wang K. N. Houk Chuang-Chuang Li
author_sort	Bao-Long Hou
title	Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
title_short	Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
title_full	Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
title_fullStr	Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
title_full_unstemmed	Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
title_sort	facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/627bce7cc54a425fbd80ac8222aa7cd9
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Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions

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