Neratinib protects pancreatic beta cells in diabetes

Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.

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Autores principales:	Amin Ardestani, Sijia Li, Karthika Annamalai, Blaz Lupse, Shirin Geravandi, Aleksandra Dobrowolski, Shan Yu, Siying Zhu, Tyler D. Baguley, Murali Surakattula, Janina Oetjen, Lena Hauberg-Lotte, Raquel Herranz, Sushil Awal, Delsi Altenhofen, Van Nguyen-Tran, Sean Joseph, Peter G. Schultz, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen, Kathrin Maedler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/627d0ae36e6e4ac994b3607b5e658ae4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:627d0ae36e6e4ac994b3607b5e658ae42021-12-02T16:58:28ZNeratinib protects pancreatic beta cells in diabetes10.1038/s41467-019-12880-52041-1723https://doaj.org/article/627d0ae36e6e4ac994b3607b5e658ae42019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12880-5https://doaj.org/toc/2041-1723Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.Amin ArdestaniSijia LiKarthika AnnamalaiBlaz LupseShirin GeravandiAleksandra DobrowolskiShan YuSiying ZhuTyler D. BaguleyMurali SurakattulaJanina OetjenLena Hauberg-LotteRaquel HerranzSushil AwalDelsi AltenhofenVan Nguyen-TranSean JosephPeter G. SchultzArnab K. ChatterjeeNikki RogersMatthew S. TremblayWeijun ShenKathrin MaedlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amin Ardestani Sijia Li Karthika Annamalai Blaz Lupse Shirin Geravandi Aleksandra Dobrowolski Shan Yu Siying Zhu Tyler D. Baguley Murali Surakattula Janina Oetjen Lena Hauberg-Lotte Raquel Herranz Sushil Awal Delsi Altenhofen Van Nguyen-Tran Sean Joseph Peter G. Schultz Arnab K. Chatterjee Nikki Rogers Matthew S. Tremblay Weijun Shen Kathrin Maedler Neratinib protects pancreatic beta cells in diabetes
description	Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.
format	article
author	Amin Ardestani Sijia Li Karthika Annamalai Blaz Lupse Shirin Geravandi Aleksandra Dobrowolski Shan Yu Siying Zhu Tyler D. Baguley Murali Surakattula Janina Oetjen Lena Hauberg-Lotte Raquel Herranz Sushil Awal Delsi Altenhofen Van Nguyen-Tran Sean Joseph Peter G. Schultz Arnab K. Chatterjee Nikki Rogers Matthew S. Tremblay Weijun Shen Kathrin Maedler
author_facet	Amin Ardestani Sijia Li Karthika Annamalai Blaz Lupse Shirin Geravandi Aleksandra Dobrowolski Shan Yu Siying Zhu Tyler D. Baguley Murali Surakattula Janina Oetjen Lena Hauberg-Lotte Raquel Herranz Sushil Awal Delsi Altenhofen Van Nguyen-Tran Sean Joseph Peter G. Schultz Arnab K. Chatterjee Nikki Rogers Matthew S. Tremblay Weijun Shen Kathrin Maedler
author_sort	Amin Ardestani
title	Neratinib protects pancreatic beta cells in diabetes
title_short	Neratinib protects pancreatic beta cells in diabetes
title_full	Neratinib protects pancreatic beta cells in diabetes
title_fullStr	Neratinib protects pancreatic beta cells in diabetes
title_full_unstemmed	Neratinib protects pancreatic beta cells in diabetes
title_sort	neratinib protects pancreatic beta cells in diabetes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/627d0ae36e6e4ac994b3607b5e658ae4
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Neratinib protects pancreatic beta cells in diabetes

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