A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report

Abstract Background Increasing numbers of tick-borne pathogens are being discovered, including those that infect humans. However, reports on co-infections caused by two or more tick-borne pathogens are scarce. Case presentation A 38-year-old male farmer was bitten by a hard tick, presented with feve...

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Autores principales:	Yu Zhang, Liang Jiang, Yicheng Yang, Songsong Xie, Wumei Yuan, Yuanzhi Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rickettsia raoultii Tacheng tick virus 1 Meningitis Fever Case report Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/627ebc60cb39472cb1d93a7f5e652fb0
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spelling	oai:doaj.org-article:627ebc60cb39472cb1d93a7f5e652fb02021-11-28T12:41:53ZA tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report10.1186/s12879-021-06877-z1471-2334https://doaj.org/article/627ebc60cb39472cb1d93a7f5e652fb02021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06877-zhttps://doaj.org/toc/1471-2334Abstract Background Increasing numbers of tick-borne pathogens are being discovered, including those that infect humans. However, reports on co-infections caused by two or more tick-borne pathogens are scarce. Case presentation A 38-year-old male farmer was bitten by a hard tick, presented with fever (37.7 °C), severe headache and ejection vomiting. Lumbar puncture was performed in the lateral decubitus. The cerebrospinal fluid (CSF) was clear, and analysis showed severe increased pressure (320 mm H2O), mild leukocytosis (126.0 × 106/L, mononuclear cells accounting for 73%) and elevated total protein concentration (0.92 g/L). Bacterial cultures of CSF and blood were negative. The diagnosis of Rickettsia raoultii and Tacheng tick virus 1 (TcTV-1) co-infection was confirmed by amplifying four rickettsial genetic markers and the partial small (S) RNA segment of TcTV-1 from the patient’s blood. The patient gradually recovered after treatment with levofloxacin and ribavirin. Conclusions This is the first reported co-infection case with fever and meningitis caused by R. raoultii and TcTV-1. It is vital to screen for multiple pathogens in tick-bitten patients, especially in those with severe complex symptoms.Yu ZhangLiang JiangYicheng YangSongsong XieWumei YuanYuanzhi WangBMCarticleRickettsia raoultiiTacheng tick virus 1MeningitisFeverCase reportInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rickettsia raoultii Tacheng tick virus 1 Meningitis Fever Case report Infectious and parasitic diseases RC109-216
spellingShingle	Rickettsia raoultii Tacheng tick virus 1 Meningitis Fever Case report Infectious and parasitic diseases RC109-216 Yu Zhang Liang Jiang Yicheng Yang Songsong Xie Wumei Yuan Yuanzhi Wang A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
description	Abstract Background Increasing numbers of tick-borne pathogens are being discovered, including those that infect humans. However, reports on co-infections caused by two or more tick-borne pathogens are scarce. Case presentation A 38-year-old male farmer was bitten by a hard tick, presented with fever (37.7 °C), severe headache and ejection vomiting. Lumbar puncture was performed in the lateral decubitus. The cerebrospinal fluid (CSF) was clear, and analysis showed severe increased pressure (320 mm H2O), mild leukocytosis (126.0 × 106/L, mononuclear cells accounting for 73%) and elevated total protein concentration (0.92 g/L). Bacterial cultures of CSF and blood were negative. The diagnosis of Rickettsia raoultii and Tacheng tick virus 1 (TcTV-1) co-infection was confirmed by amplifying four rickettsial genetic markers and the partial small (S) RNA segment of TcTV-1 from the patient’s blood. The patient gradually recovered after treatment with levofloxacin and ribavirin. Conclusions This is the first reported co-infection case with fever and meningitis caused by R. raoultii and TcTV-1. It is vital to screen for multiple pathogens in tick-bitten patients, especially in those with severe complex symptoms.
format	article
author	Yu Zhang Liang Jiang Yicheng Yang Songsong Xie Wumei Yuan Yuanzhi Wang
author_facet	Yu Zhang Liang Jiang Yicheng Yang Songsong Xie Wumei Yuan Yuanzhi Wang
author_sort	Yu Zhang
title	A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
title_short	A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
title_full	A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
title_fullStr	A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
title_full_unstemmed	A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report
title_sort	tick bite patient with fever and meningitis co-infected with rickettsia raoultii and tacheng tick virus 1: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/627ebc60cb39472cb1d93a7f5e652fb0
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A tick bite patient with fever and meningitis co-infected with Rickettsia raoultii and Tacheng tick virus 1: a case report

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