Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study

Introduction: Post-operative blood loss in lower limb trauma fractures increases morbidity. Very few studies have evaluated the efficacy of Tranexamic Acid (TXA) in reducing blood loss and the consequent requirement of blood transfusion in the Indian population. Methods: This was a randomized contro...

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Autores principales:	Kaur Gurleen, Selhi Harpal Singh, Delmotra Naresh Jyoti, Singh Jaspreet
Formato:	article
Lenguaje:	EN
Publicado:	EDP Sciences 2021
Materias:	tranexamic acid deep vein thrombosis blood transfusion Orthopedic surgery RD701-811
Acceso en línea:	https://doaj.org/article/627edca3f03a443680070001ea8ec83e
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spelling	oai:doaj.org-article:627edca3f03a443680070001ea8ec83e2021-11-08T15:22:15ZTranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study2426-888710.1051/sicotj/2021053https://doaj.org/article/627edca3f03a443680070001ea8ec83e2021-01-01T00:00:00Zhttps://www.sicot-j.org/articles/sicotj/full_html/2021/01/sicotj210072/sicotj210072.htmlhttps://doaj.org/toc/2426-8887Introduction: Post-operative blood loss in lower limb trauma fractures increases morbidity. Very few studies have evaluated the efficacy of Tranexamic Acid (TXA) in reducing blood loss and the consequent requirement of blood transfusion in the Indian population. Methods: This was a randomized controlled study of 100 patients with lower limb trauma. Fifty patients were given 1 g of TXA before surgery, and 50 patients were not given TXA. The requirement of blood transfusion, fall in Hb, the number of days admitted in the hospital after surgery were recorded, and evidence of deep vein thrombosis (DVT) was monitored. Results: Baseline demographics between the groups were comparable. The required blood transfusion and fall in Hb in patients receiving intra-operative TXA were significantly lower than those not given TXA (p < 0.0001). There was no significant difference in the length of hospital stay between the two groups (p = 0.6). There was no significant difference in the incidence of DVT in both groups. Discussion: TXA helps reduce the morbidity of trauma patients by reducing the requirement for blood transfusion. Its use is safe in lower limb trauma surgery and lowers the cost of therapy to the patient.Kaur GurleenSelhi Harpal SinghDelmotra Naresh JyotiSingh JaspreetEDP Sciencesarticletranexamic aciddeep vein thrombosisblood transfusionOrthopedic surgeryRD701-811ENSICOT-J, Vol 7, p 53 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tranexamic acid deep vein thrombosis blood transfusion Orthopedic surgery RD701-811
spellingShingle	tranexamic acid deep vein thrombosis blood transfusion Orthopedic surgery RD701-811 Kaur Gurleen Selhi Harpal Singh Delmotra Naresh Jyoti Singh Jaspreet Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
description	Introduction: Post-operative blood loss in lower limb trauma fractures increases morbidity. Very few studies have evaluated the efficacy of Tranexamic Acid (TXA) in reducing blood loss and the consequent requirement of blood transfusion in the Indian population. Methods: This was a randomized controlled study of 100 patients with lower limb trauma. Fifty patients were given 1 g of TXA before surgery, and 50 patients were not given TXA. The requirement of blood transfusion, fall in Hb, the number of days admitted in the hospital after surgery were recorded, and evidence of deep vein thrombosis (DVT) was monitored. Results: Baseline demographics between the groups were comparable. The required blood transfusion and fall in Hb in patients receiving intra-operative TXA were significantly lower than those not given TXA (p < 0.0001). There was no significant difference in the length of hospital stay between the two groups (p = 0.6). There was no significant difference in the incidence of DVT in both groups. Discussion: TXA helps reduce the morbidity of trauma patients by reducing the requirement for blood transfusion. Its use is safe in lower limb trauma surgery and lowers the cost of therapy to the patient.
format	article
author	Kaur Gurleen Selhi Harpal Singh Delmotra Naresh Jyoti Singh Jaspreet
author_facet	Kaur Gurleen Selhi Harpal Singh Delmotra Naresh Jyoti Singh Jaspreet
author_sort	Kaur Gurleen
title	Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
title_short	Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
title_full	Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
title_fullStr	Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
title_full_unstemmed	Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
title_sort	tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/627edca3f03a443680070001ea8ec83e
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Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study

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