Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>

Students can have difficulty comprehending complex concepts in science. They can memorize the definition but do not understand the underlying biological principles. In the Fundamentals of Genetics course at Arizona State University at the West campus, students grapple with the topic of “extensions o...

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Autor principal:	Pamela A. Marshall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2008
Materias:	Special aspects of education LC8-6691 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6281e49626d84fe19c1a56bcfd1539fc
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spelling	oai:doaj.org-article:6281e49626d84fe19c1a56bcfd1539fc2021-11-15T15:03:51ZDevelopment of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>10.1128/jmbe.v9.901935-78851935-7877https://doaj.org/article/6281e49626d84fe19c1a56bcfd1539fc2008-01-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/jmbe.v9.90https://doaj.org/toc/1935-7877https://doaj.org/toc/1935-7885Students can have difficulty comprehending complex concepts in science. They can memorize the definition but do not understand the underlying biological principles. In the Fundamentals of Genetics course at Arizona State University at the West campus, students grapple with the topic of “extensions of Mendelism.” Additionally, in lab, students are challenged by scoring phenotypes that are not binary. Both of these concepts require that students understand not only inheritance but also the principles of protein structure and function. A genetics laboratory exercise was developed that combines study of some extensions of Mendelian inheritance with practice in manipulating Drosophila melanogaster and scoring subtle and variable phenotypes. Students analyze Drosophila with mutations that demonstrate some extensions of Mendelian inheritance: temperature sensitivity, variable expressivity, incomplete penetrance, multiple alleles, dosage compensation, and gene dosage effect. The phenotypes in some of these mutants differ from individual to individual and are difficult to discern; thus, students also gain experience in investigating challenging phenotypes. Pre- and postlab assessments indicate that performing this exercise increased students’ mastery of the molecular basis of extensions of Mendelian inheritance and their abilities in scoring and manipulating flies. This is a discovery-based lab exercise in which students examine some extensions of Mendelian inheritance and gain experience in analyzing complex traits in Drosophila.Pamela A. MarshallAmerican Society for MicrobiologyarticleSpecial aspects of educationLC8-6691Biology (General)QH301-705.5ENJournal of Microbiology & Biology Education, Vol 9, Iss 1, Pp 12-24 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Special aspects of education LC8-6691 Biology (General) QH301-705.5
spellingShingle	Special aspects of education LC8-6691 Biology (General) QH301-705.5 Pamela A. Marshall Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
description	Students can have difficulty comprehending complex concepts in science. They can memorize the definition but do not understand the underlying biological principles. In the Fundamentals of Genetics course at Arizona State University at the West campus, students grapple with the topic of “extensions of Mendelism.” Additionally, in lab, students are challenged by scoring phenotypes that are not binary. Both of these concepts require that students understand not only inheritance but also the principles of protein structure and function. A genetics laboratory exercise was developed that combines study of some extensions of Mendelian inheritance with practice in manipulating Drosophila melanogaster and scoring subtle and variable phenotypes. Students analyze Drosophila with mutations that demonstrate some extensions of Mendelian inheritance: temperature sensitivity, variable expressivity, incomplete penetrance, multiple alleles, dosage compensation, and gene dosage effect. The phenotypes in some of these mutants differ from individual to individual and are difficult to discern; thus, students also gain experience in investigating challenging phenotypes. Pre- and postlab assessments indicate that performing this exercise increased students’ mastery of the molecular basis of extensions of Mendelian inheritance and their abilities in scoring and manipulating flies. This is a discovery-based lab exercise in which students examine some extensions of Mendelian inheritance and gain experience in analyzing complex traits in Drosophila.
format	article
author	Pamela A. Marshall
author_facet	Pamela A. Marshall
author_sort	Pamela A. Marshall
title	Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
title_short	Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
title_full	Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
title_fullStr	Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
title_full_unstemmed	Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>
title_sort	development of higher-level cognitive skills in a learner-centered lab on extensions of mendelian inheritance using <italic toggle="yes">drosophila</italic>
publisher	American Society for Microbiology
publishDate	2008
url	https://doaj.org/article/6281e49626d84fe19c1a56bcfd1539fc
work_keys_str_mv	AT pamelaamarshall developmentofhigherlevelcognitiveskillsinalearnercenteredlabonextensionsofmendelianinheritanceusingitalictoggleyesdrosophilaitalic
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Development of Higher-Level Cognitive Skills In a Learner-Centered Lab on Extensions of Mendelian Inheritance Using <italic toggle="yes">Drosophila</italic>

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