Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial

Abstract Expanded hemodialysis (HDx) with medium cutoff (MCO) membranes, which remove middle-to-large molecules well, may be a good option to replace online hemodiafiltration (online-HDF). To provide more evidence, this randomized controlled trial compared several cardiovascular parameters between p...

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Autores principales:	Yeonhee Lee, Myoung-jin Jang, Junseok Jeon, Jung Eun Lee, Wooseong Huh, Bum Soon Choi, Cheol Whee Park, Ho Jun Chin, Chae Lin Kang, Dong Ki Kim, Seung Seok Han, Kwon Wook Joo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6285117f331e4cd49f04b3be296e99af
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spelling	oai:doaj.org-article:6285117f331e4cd49f04b3be296e99af2021-12-02T15:49:42ZCardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial10.1038/s41598-021-90311-62045-2322https://doaj.org/article/6285117f331e4cd49f04b3be296e99af2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90311-6https://doaj.org/toc/2045-2322Abstract Expanded hemodialysis (HDx) with medium cutoff (MCO) membranes, which remove middle-to-large molecules well, may be a good option to replace online hemodiafiltration (online-HDF). To provide more evidence, this randomized controlled trial compared several cardiovascular parameters between patients undergoing HDx and online-HDF. Eighty patients undergoing thrice-weekly hemodialysis were randomly assigned to receive either HDx with a Theranova membrane (n = 43) or online-HDF (n = 37). The primary endpoints were changes in brachial-ankle pulse wave velocity (baPWV), echocardiographic parameters, and coronary artery calcium (CAC) scores over 1 year, and the secondary endpoints included blood cardiovascular biomarkers, mortality, and patient-reported outcomes. A linear mixed model and log-rank test were used to estimate the group differences. 65 patients had completed the trial. The changes in baPWV and echocardiographic parameters did not differ between the two groups. The CAC scores remained stable in the online-HDF group, whereas an increasing trend was shown in the HDx group (P = 0.012). Other endpoints, including cardiovascular and all-cause mortalities, were similar between the two groups. The changes in cardiovascular parameters did not differ between HDx with an MCO membrane and online-HDF. However, attention may be needed in patients with high CAC scores or scores with an increasing tendency when online-HDF is replaced with HDx with an MCO membrane.Yeonhee LeeMyoung-jin JangJunseok JeonJung Eun LeeWooseong HuhBum Soon ChoiCheol Whee ParkHo Jun ChinChae Lin KangDong Ki KimSeung Seok HanKwon Wook JooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeonhee Lee Myoung-jin Jang Junseok Jeon Jung Eun Lee Wooseong Huh Bum Soon Choi Cheol Whee Park Ho Jun Chin Chae Lin Kang Dong Ki Kim Seung Seok Han Kwon Wook Joo Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
description	Abstract Expanded hemodialysis (HDx) with medium cutoff (MCO) membranes, which remove middle-to-large molecules well, may be a good option to replace online hemodiafiltration (online-HDF). To provide more evidence, this randomized controlled trial compared several cardiovascular parameters between patients undergoing HDx and online-HDF. Eighty patients undergoing thrice-weekly hemodialysis were randomly assigned to receive either HDx with a Theranova membrane (n = 43) or online-HDF (n = 37). The primary endpoints were changes in brachial-ankle pulse wave velocity (baPWV), echocardiographic parameters, and coronary artery calcium (CAC) scores over 1 year, and the secondary endpoints included blood cardiovascular biomarkers, mortality, and patient-reported outcomes. A linear mixed model and log-rank test were used to estimate the group differences. 65 patients had completed the trial. The changes in baPWV and echocardiographic parameters did not differ between the two groups. The CAC scores remained stable in the online-HDF group, whereas an increasing trend was shown in the HDx group (P = 0.012). Other endpoints, including cardiovascular and all-cause mortalities, were similar between the two groups. The changes in cardiovascular parameters did not differ between HDx with an MCO membrane and online-HDF. However, attention may be needed in patients with high CAC scores or scores with an increasing tendency when online-HDF is replaced with HDx with an MCO membrane.
format	article
author	Yeonhee Lee Myoung-jin Jang Junseok Jeon Jung Eun Lee Wooseong Huh Bum Soon Choi Cheol Whee Park Ho Jun Chin Chae Lin Kang Dong Ki Kim Seung Seok Han Kwon Wook Joo
author_facet	Yeonhee Lee Myoung-jin Jang Junseok Jeon Jung Eun Lee Wooseong Huh Bum Soon Choi Cheol Whee Park Ho Jun Chin Chae Lin Kang Dong Ki Kim Seung Seok Han Kwon Wook Joo
author_sort	Yeonhee Lee
title	Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
title_short	Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
title_full	Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
title_fullStr	Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
title_full_unstemmed	Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial
title_sort	cardiovascular risk comparison between expanded hemodialysis using theranova and online hemodiafiltration (cartoon): a multicenter randomized controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6285117f331e4cd49f04b3be296e99af
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Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial

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